Kraemer, R; Latzin, P; Pramana, I; Ballinari, P; Gallati, S; Frey, U (2009). Long-term gas exchange characteristics as marker of deterioration in patients with cystic fibrosis. Respiratory research, 10(106), [1-12]. London: BioMed Central 10.1186/1465-9921-10-106
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Background and Aim
In patients with cystic fibrosis (CF) the architecture of the developing lungs and the ventilation of lung units are progressively affected, influencing intrapulmonary gas mixing and gas exchange. We examined the long-term course of blood gas measurements in relation to characteristics of lung function and the influence of different CFTR genotype upon this process.
Methods
Serial annual measurements of PaO2 and PaCO2 assessed in relation to lung function, providing functional residual capacity (FRCpleth), lung clearance index (LCI), trapped gas (VTG), airway resistance (sReff), and forced expiratory indices (FEV1, FEF50), were collected in 178 children (88 males; 90 females) with CF, over an age range of 5 to 18 years. Linear mixed model analysis and binary logistic regression analysis were used to define predominant lung function parameters influencing oxygenation and carbon dioxide elimination.
Results
PaO2 decreased linearly from age 5 to 18 years, and was mainly associated with FRCpleth, (p < 0.0001), FEV1 (p < 0.001), FEF50 (p < 0.002), and LCI (p < 0.002), indicating that oxygenation was associated with the degree of pulmonary hyperinflation, ventilation inhomogeneities and impeded airway function. PaCO2 showed a transitory phase of low PaCO2 values, mainly during the age range of 5 to 12 years. Both PaO2 and PaCO2 presented with different progression slopes within specific CFTR genotypes.
Conclusion
In the long-term evaluation of gas exchange characteristics, an association with different lung function patterns was found and was closely related to specific genotypes. Early examination of blood gases may reveal hypocarbia, presumably reflecting compensatory mechanisms to improve oxygenation.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine 07 Faculty of Human Sciences > Institute of Psychology > Cognitive Psychology, Perception and Methodology |
UniBE Contributor: |
Kraemer, Richard, Latzin, Philipp, Pramana, Isabelle Adriane, Ballinari, Pietro, Gallati, Sabina, Frey, Urs Peter |
ISSN: |
1465-9921 |
Publisher: |
BioMed Central |
Language: |
English |
Submitter: |
Anette van Dorland |
Date Deposited: |
04 Oct 2013 15:12 |
Last Modified: |
05 Dec 2022 14:22 |
Publisher DOI: |
10.1186/1465-9921-10-106 |
PubMed ID: |
19909502 |
Web of Science ID: |
000272292100001 |
BORIS DOI: |
10.7892/boris.31802 |
URI: |
https://boris.unibe.ch/id/eprint/31802 (FactScience: 196497) |
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