Targeting Myc in pediatric malignancies of the central and peripheral nervous system

Grotzer, Michael A; Castelletti, Deborah; Fiaschetti, Giulio; Shalaby, Tarek; Arcaro, Alexandre (2009). Targeting Myc in pediatric malignancies of the central and peripheral nervous system. Current cancer drug targets, 9(2), pp. 176-88. Hilversum: Bentham Science Publishers 10.2174/156800909787580962

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Myc family genes are often deregulated in embryonal tumors of childhood including medulloblastoma and neuroblastoma and are frequently associated with aggressive, poorly differentiated tumors. The Myc protein is a transcription factor that regulates a variety of cellular processes including cell growth and proliferation, cell cycle progression, differentiation, apoptosis, and cell motility. Potential strategies that either inhibit the proliferation-promoting effect of Myc and/or activate its pro-apoptotic function are presently being explored. In this review, we will give an overview of Myc activation in embryonal tumors and discuss current strategies aimed at targeting Myc for cancer treatment.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Arcaro, Alexandre

ISSN:

1568-0096

Publisher:

Bentham Science Publishers

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:13

Last Modified:

04 May 2014 23:23

Publisher DOI:

10.2174/156800909787580962

PubMed ID:

19275758

Web of Science ID:

000265096800006

URI:

https://boris.unibe.ch/id/eprint/32284 (FactScience: 197330)

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