Grotzer, Michael A; Castelletti, Deborah; Fiaschetti, Giulio; Shalaby, Tarek; Arcaro, Alexandre (2009). Targeting Myc in pediatric malignancies of the central and peripheral nervous system. Current cancer drug targets, 9(2), pp. 176-88. Hilversum: Bentham Science Publishers 10.2174/156800909787580962
Full text not available from this repository. (Request a copy)Myc family genes are often deregulated in embryonal tumors of childhood including medulloblastoma and neuroblastoma and are frequently associated with aggressive, poorly differentiated tumors. The Myc protein is a transcription factor that regulates a variety of cellular processes including cell growth and proliferation, cell cycle progression, differentiation, apoptosis, and cell motility. Potential strategies that either inhibit the proliferation-promoting effect of Myc and/or activate its pro-apoptotic function are presently being explored. In this review, we will give an overview of Myc activation in embryonal tumors and discuss current strategies aimed at targeting Myc for cancer treatment.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine |
UniBE Contributor: |
Arcaro, Alexandre |
ISSN: |
1568-0096 |
Publisher: |
Bentham Science Publishers |
Language: |
English |
Submitter: |
Anette van Dorland |
Date Deposited: |
04 Oct 2013 15:13 |
Last Modified: |
05 Dec 2022 14:22 |
Publisher DOI: |
10.2174/156800909787580962 |
PubMed ID: |
19275758 |
Web of Science ID: |
000265096800006 |
URI: |
https://boris.unibe.ch/id/eprint/32284 (FactScience: 197330) |
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