Corazza, Nadia; Brunner, Thomas; Buri, Caroline; Rihs, Silvia; Imboden, Martin A; Seibold, Inge; Mueller, Christoph (2004). Transmembrane tumor necrosis factor is a potent inducer of colitis even in the absence of its secreted form. Gastroenterology, 127(3), pp. 816-25. Philadelphia, Pa.: Elsevier 10.1053/j.gastro.2004.06.036
Full text not available from this repository.Tumor necrosis factor (TNF) is cleaved proteolytically from a 26-kilodalton transmembrane precursor protein into secreted 17-kilodalton monomers. Transmembrane (tm) and secreted trimeric TNF are biologically active and may mediate distinct activities. We assessed the consequences of a complete inhibition of TNF processing on the course of colitis in recombination activating gene (RAG)2 -/- mice on transfer of CD4 CD45RB hi T cells.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition |
UniBE Contributor: |
Buri, Caroline, Müller, Christoph (C) |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
0016-5085 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:23 |
Last Modified: |
29 Mar 2023 23:33 |
Publisher DOI: |
10.1053/j.gastro.2004.06.036 |
PubMed ID: |
15362037 |
Web of Science ID: |
000223834500018 |
URI: |
https://boris.unibe.ch/id/eprint/37213 (FactScience: 207220) |
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