Arachnomelia in Brown Swiss cattle maps to chromosome 5

Drögemüller, Cord; Rossi, M.; Gentile, A.; Testoni, S.; Jorg, H.; Stranzinger, G.; Drögemüller, Michaela; Glowatzki-Mullis, M.L.; Leeb, Tosso (2009). Arachnomelia in Brown Swiss cattle maps to chromosome 5. Mammalian genome, 20(1), pp. 53-59. New York, N.Y.: Springer-Verlag 10.1007/s00335-008-9157-2

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Arachnomelia in Brown Swiss cattle is a monogenic autosomal recessive inherited congenital disorder of the skeletal system giving affected calves a spidery look (OMIA ID 000059). Over a period of 20 years 15 cases were sampled in the Swiss and Italian Brown cattle population. Pedigree data revealed that all affected individuals trace back to a single acknowledged carrier founder sire. A genome scan using 240 microsatellites spanning the 29 bovine autosomes showed homozygosity at three adjacent microsatellite markers on bovine Chr 5 in all cases. Linkage analysis confirmed the localization of the arachnomelia mutation in the region of the marker ETH10. Fine-mapping and haplotype analysis using a total of 34 markers in this region refined the critical region of the arachnomelia locus to a 7.19-Mb interval on bovine Chr 5. The disease-associated IBD haplotype was shared by 36 proven carrier animals and allows marker-assisted selection. As the corresponding human and mouse chromosome segments do not contain any clear functional candidate genes for this disorder, the mutation causing arachnomelia in the Brown Swiss cattle might help to identify an unknown gene in bone development.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics

UniBE Contributor:

Drögemüller, Cord; Drögemüller, Michaela and Leeb, Tosso

Subjects:

500 Science > 590 Animals (Zoology)
600 Technology > 630 Agriculture

ISSN:

0938-8990

Publisher:

Springer-Verlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:25

Last Modified:

26 Jun 2018 14:40

Publisher DOI:

10.1007/s00335-008-9157-2

Web of Science ID:

000262651800006

BORIS DOI:

10.7892/boris.38305

URI:

https://boris.unibe.ch/id/eprint/38305 (FactScience: 220962)

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