Preemptive carprofen for peri-operative analgesia in dogs undergoing Tibial Plateau Leveling Osteotomy (TPLO): a prospective, randomized, blinded, placebo controlled clinical trial

Bufalari, A.; Maggio, C.; Cerasoli, I.; Morath, Ute; Adami, Chiara (2012). Preemptive carprofen for peri-operative analgesia in dogs undergoing Tibial Plateau Leveling Osteotomy (TPLO): a prospective, randomized, blinded, placebo controlled clinical trial. Schweizer Archiv für Tierheilkunde, 154(3), pp. 105-11. Bern: Huber 10.1024/0036-7281/a000308

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Eighteen client-owned dogs undergoing Tibial Plateau Leveling Osteotomy (TPLO) were included in this blinded clinical study and randomly assigned to one of two treatment groups. Group C (carprofen) received intravenous (IV) carprofen, 4 mg/kg, prior to anesthesia, whereas group P (placebo) received IV saline. General anesthesia was maintained with isoflurane in oxygen and a constant rate infusion (CRI) of sufentanyl IV. Intra-operatively, assessment of nociception was based on changes in physiological parameters and on the analgesics requirement, whereas in the post-operative period evaluation of pain was performed by using a Hellyer and Gaynor pain score and by comparing the doses of rescue buprenorphine required by the two treatment groups. Although no statistically significant differences in intra-operative sufentanyl doses were found between treatment groups, group C had superior cardiovascular stability, and lower post-operative pain scores and rescue buprenorphine doses than group P. Our results indicate that administration of carprofen prior to surgery was effective in improving peri-operative analgesia in dogs undergoing TPLO.

Item Type:	Journal Article (Original Article)
Division/Institute:	05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Anaesthesiology
UniBE Contributor:	Morath, Ute, Adami, Chiara
ISSN:	0036-7281
Publisher:	Huber
Language:	English
Submitter:	Andrea Stettler
Date Deposited:	15 Nov 2013 12:16
Last Modified:	05 Dec 2022 14:26
Publisher DOI:	10.1024/0036-7281/a000308
PubMed ID:	22378051
Additional Information:	Notes: Bufalari, A Maggio, C Cerasoli, I Morath, U Adami, C Switzerland Schweizer Archiv fur Tierheilkunde Schweiz Arch Tierheilkd. 2012 Mar;154(3):105-11. Edition: 2012/03/02 Date: Mar
URI:	https://boris.unibe.ch/id/eprint/38982