Baur, Roland; Gertsch, Jürg; Sigel, Erwin (2013). Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β 2 subunit of GABA A receptors? PeerJ, 1, e149. PeerJ, Ltd 10.7717/peerj.149
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NA-glycine is an endogenous lipid molecule with analgesic properties, which is structurally similar to the endocannabinoids 2-AG and anandamide but does not interact with cannabinoid receptors. NA-glycine has been suggested to act at the G-protein coupled receptors GPR18 and GPR92. Recently, we have described that NA-glycine can also modulate recombinant α1β2γ2 GABAA receptors. Here we characterize in more detail this modulation and investigate the relationship of its binding site with that of the endocannabinoid 2-AG.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine |
UniBE Contributor: |
Baur, Roland, Gertsch, Jürg, Sigel, Erwin |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
2167-8359 |
Publisher: |
PeerJ, Ltd |
Language: |
English |
Submitter: |
Erwin Sigel |
Date Deposited: |
17 Apr 2014 09:17 |
Last Modified: |
05 Dec 2022 14:27 |
Publisher DOI: |
10.7717/peerj.149 |
PubMed ID: |
24058880 |
Uncontrolled Keywords: |
GABAA receptors, Endocannabinoids, GABA, 2-AG, NA-glycine |
BORIS DOI: |
10.7892/boris.39561 |
URI: |
https://boris.unibe.ch/id/eprint/39561 |
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