Single-dose piracetam effects on global complexity measures of human spontaneous multichannel EEG

Kondakor, Istvan; Michel, Christoph M.; Wackermann, Jiri; Koenig, Thomas; Tanaka, Hideaki; Peuvot, Jacques; Lehmann, Dietrich (1999). Single-dose piracetam effects on global complexity measures of human spontaneous multichannel EEG. International journal of psychophysiology, 34(1), pp. 81-87. Elsevier 10.1016/S0167-8760(99)00044-6

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Global complexity of 47-channel resting electroencephalogram (EEG) of healthy young volunteers was studied after intake of a single dose of a nootropic drug (piracetam, Nootropil® UCB Pharma) in 12 healthy volunteers. Four treatment levels were used: 2.4, 4.8, 9.6 g piracetam and placebo. Brain electric activity was assessed through Global Dimensional Complexity and Global Omega-Complexity as quantitative measures of the complexity of the trajectory of multichannel EEG in state space. After oral ingestion (1–1.5 h), both measures showed significant decreases from placebo to 2.4 g piracetam. In addition, Global Dimensional Complexity showed a significant return to placebo values at 9.6 g piracetam. The results indicate that a single dose of piracetam dose-dependently affects the spontaneous EEG in normal volunteers, showing effects at the lowest treatment level. The decreased EEG complexity is interpreted as increased cooperativity of brain functional processes.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)

UniBE Contributor:

König, Thomas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0167-8760

Publisher:

Elsevier

Language:

English

Submitter:

Thomas König

Date Deposited:

14 Aug 2014 16:46

Last Modified:

12 Dec 2014 00:30

Publisher DOI:

10.1016/S0167-8760(99)00044-6

PubMed ID:

10555876

Uncontrolled Keywords:

Human multichannel EEG, EEG state space, Global omega complexity, Global dimensional complexity, Single dose piracetam, Piracetam effects, Brain dynamics

BORIS DOI:

10.7892/boris.39733

URI:

https://boris.unibe.ch/id/eprint/39733

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