Kondakor, Istvan; Michel, Christoph M.; Wackermann, Jiri; Koenig, Thomas; Tanaka, Hideaki; Peuvot, Jacques; Lehmann, Dietrich (1999). Single-dose piracetam effects on global complexity measures of human spontaneous multichannel EEG. International journal of psychophysiology, 34(1), pp. 81-87. Elsevier 10.1016/S0167-8760(99)00044-6
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Global complexity of 47-channel resting electroencephalogram (EEG) of healthy young volunteers was studied after intake of a single dose of a nootropic drug (piracetam, Nootropil® UCB Pharma) in 12 healthy volunteers. Four treatment levels were used: 2.4, 4.8, 9.6 g piracetam and placebo. Brain electric activity was assessed through Global Dimensional Complexity and Global Omega-Complexity as quantitative measures of the complexity of the trajectory of multichannel EEG in state space. After oral ingestion (1–1.5 h), both measures showed significant decreases from placebo to 2.4 g piracetam. In addition, Global Dimensional Complexity showed a significant return to placebo values at 9.6 g piracetam. The results indicate that a single dose of piracetam dose-dependently affects the spontaneous EEG in normal volunteers, showing effects at the lowest treatment level. The decreased EEG complexity is interpreted as increased cooperativity of brain functional processes.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology [discontinued] |
UniBE Contributor: |
König, Thomas |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0167-8760 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Thomas König |
Date Deposited: |
14 Aug 2014 16:46 |
Last Modified: |
05 Dec 2022 14:27 |
Publisher DOI: |
10.1016/S0167-8760(99)00044-6 |
PubMed ID: |
10555876 |
Uncontrolled Keywords: |
Human multichannel EEG, EEG state space, Global omega complexity, Global dimensional complexity, Single dose piracetam, Piracetam effects, Brain dynamics |
BORIS DOI: |
10.7892/boris.39733 |
URI: |
https://boris.unibe.ch/id/eprint/39733 |
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