Intensity-modulated radiotherapy for a rendu-osler-weber disease patient with recurrent severe epistaxis: a case report

Niyazi, Maximilian; Caversaccio, Marco-Domenico; Dubach, Patrick; Geretschläger, Andreas; Arnold, Andreas; Belka, Claus; Aebersold, Daniel M; Blumstein, Norbert M (2010). Intensity-modulated radiotherapy for a rendu-osler-weber disease patient with recurrent severe epistaxis: a case report. Case reports in medicine, 2010, p. 321835. New York, N.Y.: Hindawi Publishing Corporation 10.1155/2010/321835

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We present a case of a Rendu-Osler-Weber disease patient with recurrent life threatening epistaxis demanding multiple blood transfusions despite of repetitive endoscopic laser and electrocoagulations, endovascular embolisation, septodermoplasty, and long-term intranasal dressings. As alternative treatment modalities repeatedly failed and the patient became almost permanently dependent on nasal dressing, we performed a highly conformal intensity-modulated radiotherapy of the nasal cavity; a total dose of 50 Gy in 2 Gy single fractions was applied. The therapy was very well tolerated, no acute toxicities occurred. Two weeks after the last radiation dose had been applied, the nasal dressing could be removed without problems. Endoscopical control revealed an almost avascular white mucosa without any trace of bleeding spots; previously existing hemangiomas and crusts had disappeared. After a 1-year-follow up, the patient had no significant recurrent epistaxis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Caversaccio, Marco; Dubach, Patrick; Geretschläger, Andreas; Aebersold, Daniel and Blumstein, Norbert Manfred

ISSN:

1687-9627

Publisher:

Hindawi Publishing Corporation

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:08

Last Modified:

15 Dec 2014 11:27

Publisher DOI:

10.1155/2010/321835

PubMed ID:

20368796

Web of Science ID:

000269719400097

BORIS DOI:

10.7892/boris.399

URI:

https://boris.unibe.ch/id/eprint/399 (FactScience: 198395)

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