Immune recovery after starting ART in HIV-infected patients presenting and not presenting with tuberculosis in South Africa

Schomaker, Michael; Egger, Matthias; Maskew, Mhairi; Garone, Daniela; Prozesky, Hans; Hoffmann, Christopher J.; Boulle, Andrew; Fenner, Lukas (2013). Immune recovery after starting ART in HIV-infected patients presenting and not presenting with tuberculosis in South Africa. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 63(1), pp. 142-145. Lippincott Williams & Wilkins 10.1097/QAI.0b013e318288b39d

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We studied the immune response after starting antiretroviral treatment (ART) in 15,646 HIV-infected patients with or without tuberculosis (TB) at presentation in 3 ART programs in South Africa between 2003 and 2010. Patients presenting with TB had similar increases in CD4 cells compared with all other patients (adjusted difference 4.9 cells/µL per 6 months, 95% confidence interval: 0.2 to 9.7). Younger age, advanced clinical stage, female sex, and lower CD4 cell count at ART start were all associated with steeper CD4 slopes. In South Africa, HIV-infected patients presenting with TB experience immune recovery after starting ART that is no worse than in other patients.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Egger, Matthias and Fenner, Lukas

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0894-9255

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

19 Feb 2014 15:37

Last Modified:

16 Mar 2015 00:41

Publisher DOI:

10.1097/QAI.0b013e318288b39d

PubMed ID:

23364513

BORIS DOI:

10.7892/boris.40854

URI:

https://boris.unibe.ch/id/eprint/40854

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