Koch, Alexander; Pfeilschrifter, Josef; Huwiler, Andrea (2013). Sphingosine 1-phosphate in renal diseases. Cellular physiology and biochemistry, 31(6), pp. 745-760. Karger 10.1159/000350093
|
Text
000350093.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC). Download (2MB) | Preview |
Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about the physiological and pathophysiological functions of S1P in this organ have been raised. In this review, we summarize the current state of knowledge about S1P-mediated functions in the kidney. A special focus is put on S1P modulated signal transduction in renal glomerular and tubular cells and consequences for the development and treatment of several kidney diseases, diabetic nephropathy, glomerulonephritis, ischemia-reperfusion injury, as well as for Wilms tumor progression.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology |
UniBE Contributor: |
Huwiler, Andrea |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1015-8987 |
Publisher: |
Karger |
Language: |
English |
Submitter: |
Anita Dähler |
Date Deposited: |
11 Mar 2014 10:14 |
Last Modified: |
25 May 2023 15:21 |
Publisher DOI: |
10.1159/000350093 |
PubMed ID: |
23736205 |
BORIS DOI: |
10.48350/41568 |
URI: |
https://boris.unibe.ch/id/eprint/41568 |
Actions (login required)
 |
Edit item |