Lüer, Sonja; Götte, Jeannette; Troller, Rolf; Aebi, Christoph (2014). Synthetic versus natural curcumin: bioequivalence in an in vitro oral mucositis model. BMC complementary and alternative medicine, 14(1), p. 53. BioMed Central 10.1186/1472-6882-14-53
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BACKGROUND
Curcumin (CUR) is a dietary spice and food colorant (E100). Its potent anti-inflammatory activity by inhibiting the activation of Nuclear Factor-kappaB is well established.
METHODS
The aim of this study was to compare natural purified CUR (nCUR) with synthetically manufactured CUR (sCUR) with respect to their capacity to inhibit detrimental effects in an in vitro model of oral mucositis. The hypothesis was to demonstrate bioequivalence of nCUR and sCUR.
RESULTS
The purity of sCUR was HPLC-confirmed. Adherence and invasion assays for bacteria to human pharyngeal epithelial cells demonstrated equivalence of nCUR and sCUR. Standard assays also demonstrated an identical inhibitory effect on pro-inflammatory cytokine/chemokine secretion (e.g., interleukin-8, interleukin-6) by Detroit pharyngeal cells exposed to bacterial stimuli. There was bioequivalence of sCUR and nCUR with respect to their antibacterial effects against various pharyngeal species.
CONCLUSION
nCUR and sCUR are equipotent in in vitro assays mimicking aspects of oral mucositis. The advantages of sCUR include that it is odorless and tasteless, more easily soluble in DMSO, and that it is a single, highly purified molecule, lacking the batch-to-batch variation of CUR content in nCUR. sCUR is a promising agent for the development of an oral anti-mucositis agent.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases |
UniBE Contributor: |
Lüer, Sonja, Götte, Jeannette, Troller, Rolf, Aebi, Christoph |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry 600 Technology > 610 Medicine & health |
ISSN: |
1472-6882 |
Publisher: |
BioMed Central |
Language: |
English |
Submitter: |
Anette van Dorland |
Date Deposited: |
19 Feb 2014 14:38 |
Last Modified: |
05 Dec 2022 14:28 |
Publisher DOI: |
10.1186/1472-6882-14-53 |
PubMed ID: |
24517289 |
BORIS DOI: |
10.7892/boris.41738 |
URI: |
https://boris.unibe.ch/id/eprint/41738 |
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