Synthetic versus natural curcumin: bioequivalence in an in vitro oral mucositis model

Lüer, Sonja; Götte, Jeannette; Troller, Rolf; Aebi, Christoph (2014). Synthetic versus natural curcumin: bioequivalence in an in vitro oral mucositis model. BMC complementary and alternative medicine, 14(1), p. 53. BioMed Central 10.1186/1472-6882-14-53

[img]
Preview
Text
1472-6882-14-53.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (905kB) | Preview

BACKGROUND Curcumin (CUR) is a dietary spice and food colorant (E100). Its potent anti-inflammatory activity by inhibiting the activation of Nuclear Factor-kappaB is well established. METHODS The aim of this study was to compare natural purified CUR (nCUR) with synthetically manufactured CUR (sCUR) with respect to their capacity to inhibit detrimental effects in an in vitro model of oral mucositis. The hypothesis was to demonstrate bioequivalence of nCUR and sCUR. RESULTS The purity of sCUR was HPLC-confirmed. Adherence and invasion assays for bacteria to human pharyngeal epithelial cells demonstrated equivalence of nCUR and sCUR. Standard assays also demonstrated an identical inhibitory effect on pro-inflammatory cytokine/chemokine secretion (e.g., interleukin-8, interleukin-6) by Detroit pharyngeal cells exposed to bacterial stimuli. There was bioequivalence of sCUR and nCUR with respect to their antibacterial effects against various pharyngeal species. CONCLUSION nCUR and sCUR are equipotent in in vitro assays mimicking aspects of oral mucositis. The advantages of sCUR include that it is odorless and tasteless, more easily soluble in DMSO, and that it is a single, highly purified molecule, lacking the batch-to-batch variation of CUR content in nCUR. sCUR is a promising agent for the development of an oral anti-mucositis agent.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Lüer, Sonja; Götte, Jeannette; Troller, Rolf and Aebi, Christoph

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry
600 Technology > 610 Medicine & health

ISSN:

1472-6882

Publisher:

BioMed Central

Language:

English

Submitter:

André Schaller

Date Deposited:

19 Feb 2014 14:38

Last Modified:

05 Feb 2016 13:14

Publisher DOI:

10.1186/1472-6882-14-53

PubMed ID:

24517289

BORIS DOI:

10.7892/boris.41738

URI:

https://boris.unibe.ch/id/eprint/41738

Actions (login required)

Edit item Edit item
Provide Feedback