Targeting autophagy as a potential therapeutic approach for melanoma therapy

Liu, He; He, Zhaoyue; Simon, Hans-Uwe (2013). Targeting autophagy as a potential therapeutic approach for melanoma therapy. Seminars in Cancer Biology, 5(23), pp. 352-360. Elsevier 10.1016/j.semcancer.2013.06.008

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Melanoma, occurring as a rapidly progressive skin cancer, is resistant to current chemo- and radiotherapy, especially after metastases to distant organs has taken place. Most chemotherapeutic drugs exert their cytotoxic effect by inducing apoptosis, which, however, is often deficient in cancer cells. Thus, it is appropriate to attempt the targeting of alternative pathways, which regulate cellular viability. Recent studies of autophagy, a well-conserved cellular catabolic process, promise to improve the therapeutic outcome in melanoma patients. Although a dual role for autophagy in cancer therapy has been reported, both protecting against and promoting cell death, the potential for using autophagy in cancer therapy seems to be promising. Here, we review the recent literature on the role of autophagy in melanoma with respect to the expression of autophagic markers, the involvement of autophagy in chemo- and immunotherapy, as well as the role of autophagy in hypoxia and altered metabolic pathways employed for melanoma therapy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Liu, He; He, Zhaoyue and Simon, Hans-Uwe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1044-579X

Publisher:

Elsevier

Language:

English

Submitter:

Anita Dähler

Date Deposited:

04 Apr 2014 21:29

Last Modified:

22 Apr 2020 15:37

Publisher DOI:

10.1016/j.semcancer.2013.06.008

PubMed ID:

23831275

BORIS DOI:

10.7892/boris.42620

URI:

https://boris.unibe.ch/id/eprint/42620

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