Embedding of human vertebral bodies leads to higher ultimate load and altered damage localisation under axial compression

Maquer, Ghislain Bernard; Schwiedrzik, Johann Jakob; Zysset, Philippe (2014). Embedding of human vertebral bodies leads to higher ultimate load and altered damage localisation under axial compression. Computer methods in biomechanics and biomedical engineering, 17(2), pp. 1311-1322. Taylor & Francis 10.1080/10255842.2012.744400

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Computer tomography (CT)-based finite element (FE) models of vertebral bodies assess fracture load in vitro better than dual energy X-ray absorptiometry, but boundary conditions affect stress distribution under the endplates that may influence ultimate load and damage localisation under post-yield strains. Therefore, HRpQCT-based homogenised FE models of 12 vertebral bodies were subjected to axial compression with two distinct boundary conditions: embedding in polymethylmethalcrylate (PMMA) and bonding to a healthy intervertebral disc (IVD) with distinct hyperelastic properties for nucleus and annulus. Bone volume fraction and fabric assessed from HRpQCT data were used to determine the elastic, plastic and damage behaviour of bone. Ultimate forces obtained with PMMA were 22% higher than with IVD but correlated highly (R2 = 0.99). At ultimate force, distinct fractions of damage were computed in the endplates (PMMA: 6%, IVD: 70%), cortex and trabecular sub-regions, which confirms previous observations that in contrast to PMMA embedding, failure initiated underneath the nuclei in healthy IVDs. In conclusion, axial loading of vertebral bodies via PMMA embedding versus healthy IVD overestimates ultimate load and leads to distinct damage localisation and failure pattern.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute for Surgical Technology & Biomechanics ISTB

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Maquer, Ghislain Bernard; Schwiedrzik, Johann Jakob and Zysset, Philippe

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health
600 Technology > 620 Engineering

ISSN:

1025-5842

Publisher:

Taylor & Francis

Language:

English

Submitter:

Ghislain Bernard Maquer

Date Deposited:

30 Apr 2014 02:42

Last Modified:

03 Feb 2016 21:20

Publisher DOI:

10.1080/10255842.2012.744400

PubMed ID:

23237518

BORIS DOI:

10.7892/boris.42731

URI:

https://boris.unibe.ch/id/eprint/42731

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