Recurrence due to neoplastic seeding in head and neck cancer: report of two cases and review of the literature

Nisa, Lluis; Khanfir, Kaouthar; Giger, Roland (2013). Recurrence due to neoplastic seeding in head and neck cancer: report of two cases and review of the literature. Tumori, 99(4), e144-e147. Il Pensiero Scientifico Editore 10.1700/1361.15112

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AIMS AND BACKGROUND Tumor progression due to seeding of tumor cells after definitive treatment for squamous cell carcinomas of the head and neck is an uncommon condition that can considerably worsen the outcome of patients with head and neck cancer. METHODS AND STUDY DESIGN We report two cases of recurrence due to neoplastic seeding from oropharyngeal and oral cancer, respectively. We performed a literature review with MEDLINE as the main search engine. RESULTS Seeding was found to occur most often in tracheotomy scars and gastrostomy sites. The oral cavity, hypopharynx and oropharynx were the primary sites in most cases, and advanced tumor stage seemed to be a risk factor for seeding. Treatment options include salvage surgery, which requires thorough resections, radiotherapy when possible, and palliative management. The prognosis of such events is poor. CONCLUSION Although neoplastic seeding is a well-known phenomenon in cancer surgery, many questions remain unanswered, especially regarding preventive measures and management strategies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Tumor-Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Tumor-Immunologie

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)

UniBE Contributor:

Nisa, Lluis and Giger, Roland

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2038-2529

Publisher:

Il Pensiero Scientifico Editore

Language:

Italiano

Submitter:

Lilian Tschan

Date Deposited:

07 Mar 2014 12:09

Last Modified:

07 Mar 2014 12:09

Publisher DOI:

10.1700/1361.15112

PubMed ID:

24326849

URI:

https://boris.unibe.ch/id/eprint/43448

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