04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Tumor-Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Tumor-Immunologie

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Number of items at this level: 47.

2020

Riether, Carsten; Pabst, Thomas; Höpner, Sabine; Bacher, Ulrike; Hinterbrandner, Magdalena; Banz, Yara; Müller, Rouven; Manz, Markus G.; Gharib, Walid H.; Francisco, David; Bruggmann, Remy; van Rompaey, Luc; Moshir, Mahan; Delahaye, Tim; Gandini, Domenica; Erzeel, Ellen; Hultberg, Anna; Fung, Samson; de Haard, Hans; Leupin, Nicolas; ... (2020). Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents. Nature medicine, 26(9), pp. 1459-1467. Springer Nature 10.1038/s41591-020-0910-8

Amrein, M. A.; Bührer, E. D.; Amrein, M. L.; Li, Q.; Rothschild, S.; Riether, C.; Jaggi, R.; Savic-Prince, S.; Bubendorf, L.; Gautschi, O.; Ochsenbein, A. (2020). Chemotherapy negatively impacts the tumor immune microenvironment in NSCLC: an analysis of pre- and post-treatment biopsies in the multi-center SAKK19/09 study. (In Press). Cancer immunology, immunotherapy : CII Springer 10.1007/s00262-020-02688-4

Brigger, Daniel; Riether, Carsten; van Brummelen, Robin; Mosher, Kira I; Shiu, Alicia; Ding, Zhaoqing; Zbären, Noemi; Gasser, Pascal; Guntern, Pascal; Yousef, Hanadie; Castellano, Joseph M; Storni, Federico; Graff-Radford, Neill; Britschgi, Markus; Grandgirard, Denis; Hinterbrandner, Magdalena; Siegrist, Mark; Moullan, Norman; Hofstetter, Wilhelm; Leib, Stephen L.; ... (2020). Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age. Nature metabolism, 2(8), pp. 688-702. Springer Nature 10.1038/s42255-020-0228-3

Frangež, Živa; Fernández-Marrero, Yuniel; Stojkov, Darko; Seyed Jafari, S. Morteza; Hunger, Robert E.; Djonov, Valentin; Riether, Carsten; Simon, Hans-Uwe (2020). BIF-1 inhibits both mitochondrial and glycolytic ATP production: its downregulation promotes melanoma growth. Oncogene, 39(26), pp. 4944-4955. Springer Nature 10.1038/s41388-020-1339-8

Riether, Carsten; Ochsenbein, Adrian F. (2020). Genetic Alterations Impact Immune Microenvironment Interactions in Follicular Lymphoma. Cancer cell, 37(5), pp. 621-622. Cell Press 10.1016/j.ccell.2020.04.008

Jaeger-Ruckstuhl, Carla A.; Hinterbrandner, Magdalena; Höpner, Sabine; Correnti, Colin E; Lüthi, Ursina; Friedli, Olivier; Freigang, Stefan; Al Sayed, Mohamad F; Bührer, Elias D.; Amrein, Michael A.; Schürch, Christian M.; Radpour, Ramin; Riether, Carsten; Ochsenbein, Adrian F. (2020). TNIK signaling imprints CD8+ T cell memory formation early after priming. Nature communications, 11(1), p. 1632. Nature Publishing Group 10.1038/s41467-020-15413-7

Schürch, Christian M.; Rasche, Leo; Frauenfeld, Leonie; Weinhold, Niels; Fend, Falko (2020). A review on tumor heterogeneity and evolution in multiple myeloma: pathological, radiological, molecular genetics, and clinical integration. Virchows Archiv, 476(3), pp. 337-351. Springer 10.1007/s00428-019-02725-3

2019

Al Sayed, M; Amrein, Martin Lukas; Bührer, Emanuel; Huguenin, AL; Radpour, Ramin; Riether, Carsten; Ochsenbein, Adrian (2019). T-cell-Secreted TNFα Induces Emergency Myelopoiesis and Myeloid-Derived Suppressor Cell Differentiation in Cancer. Cancer research, 79(2), pp. 346-359. American Association for Cancer Research AACR 10.1158/0008-5472.CAN-17-3026

Radpour, Ramin; Riether, Carsten; Simillion, Cedric; Höpner, Sabine; Bruggmann, Rémy; Ochsenbein, Adrian (2019). CD8+ T cells expand stem and progenitor cells in favorable but not adverse risk acute myeloid leukemia. Leukemia, 33(10), pp. 2379-2392. Nature Publishing Group 10.1038/s41375-019-0441-9

Tièche, Colin; Gao, Yanyun; Bührer, Elias; Hobi, Nina; Berezowska, Sabina Anna; Wyler, Kurt; Froment, Laurène; Weis, Stefan; Peng, Ren-Wang; Bruggmann, Rémy; Schär, Primo; Amrein, Michael Alex; Hall, Sean; Dorn, Patrick; Kocher, Gregor; Riether, Carsten; Ochsenbein, Adrian; Schmid, Ralph; Marti, Thomas (2019). Tumor Initiation Capacity and Therapy Resistance Are Differential Features of EMT-Related Subpopulations in the NSCLC Cell Line A549. Neoplasia, 21(2), pp. 185-196. Elsevier 10.1016/j.neo.2018.09.008

Shun-Qing, Liang; Bührer, Elias; Berezowska, Sabina Anna; Marti, Thomas; Xu, Duo; Froment, Laurène; Yang, Haitang; Hall, Sean; Vassella, Erik; Zhang, Yang; Kocher, Gregor; Amrein, Michael Alex; Riether, Carsten; Ochsenbein, Adrian; Schmid, Ralph; Peng, Ren-Wang (2019). mTOR mediates a mechanism of resistance to chemotherapy and defines a rational combination strategy to treat KRAS-mutant lung cancer. Oncogene, 38(5), pp. 622-636. Nature Publishing Group 10.1038/s41388-018-0479-6

Burkhard, Regula; Keller, Irene; Arambasic, Miroslav; Juskevicius, Darius; Tzankov, Alexandar; Lundberg, Pontus; Bruggmann, Rémy; Dirnhofer, Stephan; Radpour, Ramin; Novak, Urban (2019). TIRAP p.R81C is a novel lymphoma risk variant which enhances cell proliferation via NF-κB mediated signaling in B-cells. Haematologica - the hematology journal, 104(4), pp. 766-777. Ferrata-Storti Foundation 10.3324/haematol.2018.201590

Mohsen, Mona O.; Vogel, Monique; Riether, Carsten; Muller, Julius; Salatino, Silvia; Ternette, Nicola; Gomes, Ariane C; Cabral-Miranda, Gustavo; El-Turabi, Aadil; Ruedl, Christiane; Kundig, Thomas M; Dermime, Said; Knuth, Alexander; Speiser, Daniel E; Bachmann, Martin F. (2019). Targeting Mutated Plus Germline Epitopes Confers Pre-clinical Efficacy of an Instantly Formulated Cancer Nano-Vaccine. Frontiers in immunology, 10, p. 1015. Frontiers Research Foundation 10.3389/fimmu.2019.01015

2018

Riether, Carsten; Pabst, Thomas; Höpner, Sabine; Bacher, Vera; Hinterbrandner, Magdalena; Banz, Yara; Müller, Rouven; Manz, Markus G.; Gharib, Walid H.; Ferreira, David; Bruggmann, Remy; Van Rompaey, Luc; Moshir, Mahan; Delahaye, Tim; Gandini, Domenica; Erzeel, Ellen; Hultberg, Anna; Fung, Samson; De Haard, Hans; Leupin, Nicolas; ... (2 December 2018). 2680 Argx-110 Targeting CD70, in Combination with Azacitidine, Shows Favorable Safety Profile and Promising Anti-Leukemia Activity in Newly Diagnosed AML Patients in an Ongoing Phase 1/2 Clinical Trial (Unpublished). In: ASCO 2018. 2. Dezember 2018.

Xu, Duo; Shun-Qing, Liang; Yang, Haitang; Lüthi, Ursina; Riether, Carsten; Berezowska, Sabina Anna; Marti, Thomas; Hall, Sean; Bruggmann, Rémy; Kocher, Gregor; Schmid, Ralph; Peng, Ren-Wang (2018). Increased sensitivity to apoptosis upon endoplasmic reticulum stress-induced activation of the unfolded protein response in chemotherapy-resistant malignant pleural mesothelioma. British journal of cancer, 119(1), pp. 65-75. Nature Publishing Group 10.1038/s41416-018-0145-3

Hensel, Janine; Wetterwald, Antoinette; Temanni, Ramzi; Keller, Irene; Riether, Carsten; van der Pluijm, Gabri; Cecchini, Marco G; Thalmann, George N. (2018). Osteolytic cancer cells induce vascular/axon guidance processes in the bone/bone marrow stroma. OncoTarget, 9(48), pp. 28877-28896. Impact Journals LLC 10.18632/oncotarget.25608

Hilmenyuk, Tamara; Ruckstuhl, Carla A.; Hayoz, Michael; Berchtold, Christian; Nuoffer, Jean-Marc; Solanki, Shyam; Keun, Hector C.; Beavis, Paul A.; Riether, Carsten; Ochsenbein, Adrian F. (2018). T cell inhibitory mechanisms in a model of aggressive Non-Hodgkin's Lymphoma. Oncoimmunology, 7(1), e1365997. Landes Bioscience 10.1080/2162402x.2017.1365997

2017

Radpour, Ramin (2017). Tracing and targeting cancer stem cells: New venture for personalized molecular cancer therapy. World journal of stem cells, 9(10), pp. 169-178. Baishideng Publishing Group 10.4252/wjsc.v9.i10.169

Aghagolzadeh, Parisa; Radpour, Ramin; Bachtler, Matthias; van Goor, Harry; Smith, Edward R; Lister, Adam; Odermatt, Alex; Feelisch, Martin; Pasch, Andreas (2017). Hydrogen sulfide attenuates calcification of vascular smooth muscle cells via KEAP1/NRF2/NQO1 activation. Atherosclerosis, 265, pp. 78-86. Elsevier 10.1016/j.atherosclerosis.2017.08.012

Rothschild, S; Amrein, Michael; Riether, Carsten; Gautschi, O; Schuster, N; Li, Q; Savic, S; Schneider, M; Biaggi, C; Bubendorf, L; Brutsche, M; Zippelius, A; Zander, T; Betticher, D; Früh, M; Stahel, R; Cathomas, R; Rauch, Daniel; Pless, M; Ochsenbein, Adrian; ... (October 2017). CCNE1, PTGS2, TGFA and WISP2 Predict Benefit from Bevacizumab and Chemotherapy in Patients with Advanced Non-Small Cell Lung Cancer (SAKK19/09). Journal of thoracic oncology, 12(11S2), S1864-S1865. Elsevier

Holtz, F; Monnier, Y; Borner, Urs; Nisa, Lluis (2017). Bilateral lingual artery stenosis: A rare, late complication of chemoradiotherapy. European annals of otorhinolaryngology, head and neck diseases, 134(4), pp. 269-271. Elsevier 10.1016/j.anorl.2017.02.002

Murone, Maximilien; Radpour, Ramin; Attinger, Antoine; Chessex, Anne Vaslin; Huguenin, Anne-Laure; Schürch, Christian M; Banz Wälti, Yara; Sengupta, Saumitra; Aguet, Michel; Rigotti, Stefania; Bachhav, Yogeshwar; Massière, Frédéric; Ramachandra, Murali; McAllister, Andres; Riether, Carsten (2017). The Multi-kinase Inhibitor Debio 0617B Reduces Maintenance and Self-renewal of Primary Human AML CD34+ Stem/Progenitor Cells. Molecular cancer therapeutics, 16(8), pp. 1497-1510. American Association for Cancer Research AACR 10.1158/1535-7163.MCT-16-0889

Al Sayed, Mohamad; Ruckstuhl, Carla Alicia; Hilmenyuk, Tamara; Claus, Christina; Bourquin, Jean-Pierre; Bornhauser, Beat C; Radpour, Ramin; Riether, Carsten; Ochsenbein, Adrian (2017). CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies. Blood, 130(3), pp. 297-309. American Society of Hematology 10.1182/blood-2016-12-756585

Buschor, Stefanie; Cuenca Vera, Miguelangel; Uster, Stephanie Sarah; Schären, Olivier; Balmer, Maria L; Terrazos Miani, Miguel Angel; Schürch, Christian M; Hapfelmeier, Siegfried Hektor (2017). Innate immunity restricts Citrobacter rodentium A/E pathogenesis initiation to an early window of opportunity. PLoS pathogens, 13(6), e1006476. Public Library of Science 10.1371/journal.ppat.1006476

Riether, Carsten; Schürch, Christian M.; Bührer, Elias D.; Hinterbrandner, Magdalena; Huguenin, Anne-Laure; Höpner, Sabine; Zlobec, Inti; Pabst, Thomas; Radpour, Ramin; Ochsenbein, Adrian F. (2017). CD70/CD27 signaling promotes blast stemness and is a viable therapeutic target in acute myeloid leukemia. The Journal of experimental medicine, 214(2), pp. 359-380. Rockefeller Univ. Press 10.1084/jem.20152008

2016

Zysset, Daniel; Weber, Benjamin; Rihs, Silvia; Brasseit, Jennifer; Freigang, Stefan Bernd; Riether, Carsten; Banz Wälti, Yara; Cerwenka, Adelheid; Simillion, Cedric; Marques-Vidal, Pedro; Ochsenbein, Adrian; Saurer, Leslie; Müller, Christoph (2016). TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis. Nature communications, 7(13151), p. 13151. Nature Publishing Group 10.1038/ncomms13151

2015

Riether, Carsten; Gschwend, T; Huguenin, Anne-Laure; Schürch, Christian; Ochsenbein, Adrian (2015). Blocking programmed cell death 1 in combination with adoptive cytotoxic T-cell transfer eradicates chronic myelogenous leukemia stem cells. Leukemia, 29(8), pp. 1781-1785. Nature Publishing Group 10.1038/leu.2015.26

Riether, Carsten; Schürch, Christian; Flury, Christoph; Hinterbrandner, Magdalena; Drück, Linda; Huguenin, Anne-Laure; Baerlocher, Gabriela M.; Radpour, Ramin; Ochsenbein, Adrian (2015). Tyrosine kinase inhibitor-induced CD70 expression mediates drug resistance in leukemia stem cells by activating Wnt signaling. Science translational medicine, 7(298), 298ra119. American Association for the Advancement of Science 10.1126/scitranslmed.aab1740

Mager, Lukas; Riether, Carsten; Schürch, Christian; Banz Wälti, Yara; Wasmer, Marie-Hélène Christin; Stuber Roos, Regula; Theocharides, Alexandre; Li, Xiaohong; Xia, Yu; Saito, Hirohisa; Nakae, Susumu; Baerlocher, Gabriela M.; Manz, Markus G; McCoy, Kathleen; Macpherson, Andrew; Ochsenbein, Adrian; Beutler, Bruce; Krebs, Philippe (2015). IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms. Journal of clinical investigation, 125(7), pp. 2579-2591. American Society for Clinical Investigation 10.1172/JCI77347

Riether, Carsten; Schürch, Christian; Ochsenbein, Adrian (2015). Regulation of hematopoietic and leukemic stem cells by the immune system. Cell death and differentiation, 22(2), pp. 187-198. Nature Publishing Group 10.1038/cdd.2014.89

2014

Balmer, Maria L; Schürch, Christian; Saito, Yasuyuki; Geuking, Markus; Li, Hai; Cuenca, Miguelangel; Kovtonyuk, Larisa V; McCoy, Kathleen; Hapfelmeier, Siegfried; Ochsenbein, Adrian; Manz, Markus G; Slack, Emma; Macpherson, Andrew (2014). Microbiota-derived compounds drive steady-state granulopoiesis via MyD88/TICAM signaling. Journal of immunology, 193(10), pp. 5273-5283. American Association of Immunologists 10.4049/jimmunol.1400762

Jörger Messerli, Marianne; Baty, F; Früh, M; Stahel, R A; Betticher, D C; von Moos, Rodica; Ochsenbein, Adrian; Pless, M; Gautschi, O; Rothschild, S; Brauchli, P; Klingbiel, Dirk; Zappa, F; Brutsche, M (2014). Circulating microRNA profiling in patients with advanced non-squamous NSCLC receiving bevacizumab/erlotinib followed by platinum-based chemotherapy at progression (SAKK 19/05). Lung cancer, 85(2), pp. 306-313. Elsevier 10.1016/j.lungcan.2014.04.014

Schürch, Christian; Riether, Carsten; Ochsenbein, Adrian (2014). Cytotoxic CD8+ T cells stimulate hematopoietic progenitors by promoting cytokine release from bone marrow mesenchymal stromal cells. Cell stem cell, 14(4), pp. 460-472. Elsevier 10.1016/j.stem.2014.01.002

Lennerz, Volker; Gross, Stefanie; Gallerani, Elisa; Sessa, Cristiana; Mach, Nicolas; Boehm, Steffen; Hess, Dagmar; von Boehmer, Lotta; Knuth, Alexander; Ochsenbein, Adrian; Gnad-Vogt, Ulrike; Zieschang, Juergen; Forssmann, Ulf; Woelfel, Thomas; Kaempgen, Eckhart (2014). Immunologic response to the survivin-derived multi-epitope vaccine EMD640744 in patients with advanced solid tumors. Cancer immunology, immunotherapy, 63(4), pp. 381-394. Springer 10.1007/s00262-013-1516-5

Eisele, Günter; Wick, Antje; Eisele, Anna-Carina; Clément, Paul M; Tonn, Jörg; Tabatabai, Ghazaleh; Ochsenbein, Adrian; Schlegel, Uwe; Neyns, Bart; Krex, Dietmar; Langenegger, Simon Matthias; Nikkhah, Guido; Picard, Martin; Stupp, Roger; Wick, Wolfgang; Weller, Michael (2014). Cilengitide treatment of newly diagnosed glioblastoma patients does not alter patterns of progression. Journal of neuro-oncology, 117(1), pp. 141-145. Springer 10.1007/s11060-014-1365-x

Weber, Benjamin; Schuster, Steffen; Zysset, Daniel; Rihs, Silvia; Dickgreber, Nina; Schürch, Christian; Riether, Carsten; Siegrist, Mark; Schneider, Christoph; Pawelski, Helga; Gurzeler, Ursina; Ziltener, Pascal; Genitsch, Vera; Tacchini-Cottier, Fabienne; Ochsenbein, Adrian; Hofstetter, Willy; Kopf, Manfred; Kaufmann, Thomas; Oxenius, Annette; Reith, Walter; ... (2014). TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance. PLoS pathogens, 10(1), e1003900. Public Library of Science 10.1371/journal.ppat.1003900

2013

Nisa, Lluis; Khanfir, Kaouthar; Giger, Roland (2013). Recurrence due to neoplastic seeding in head and neck cancer: report of two cases and review of the literature. Tumori, 99(4), e144-e147. Il Pensiero Scientifico Editore 10.1700/1361.15112

Schürch, Christian M.; Riether, Carsten; Ochsenbein, Adrian F. (2013). Interferons in hematopoiesis and leukemia. Oncoimmunology, 2(6), e24572. Landes Bioscience 10.4161/onci.24572

Schürch, Christian; Riether, Carsten; Amrein, Michael A.; Ochsenbein, Adrian F. (2013). Cytotoxic T cells induce proliferation of chronic myeloid leukemia stem cells by secreting interferon-γ. Journal of experimental medicine, 210(3), pp. 605-621. Rockefeller University Press 10.1084/jem.20121229

Riether, Carsten; Schürch, Christian; Ochsenbein, Adrian F. (2013). From "magic bullets" to specific cancer immunotherapy. Swiss medical weekly, 143, w13734. EMH Schweizerischer Ärzteverlag 10.4414/smw.2013.13734

2012

Schürch, Christian; Riether, Carsten; Matter, Matthias S; Tzankov, Alexandar; Ochsenbein, Adrian (2012). CD27 signaling on chronic myelogenous leukemia stem cells activates Wnt target genes and promotes disease progression. Journal of clinical investigation, 122(2), pp. 624-38. Ann Arbor, Mich.: American Society for Clinical Investigation 10.1172/JCI45977

Riether, Carsten; Schürch, Christian; Ochsenbein, Adrian (2012). Modulating CD27 signaling to treat cancer. Oncoimmunology, 1(9), pp. 1604-1606. Austin, Tex.: Landes Bioscience 10.4161/onci.21425

Claus, Christina; Riether, Carsten; Schürch, Christian; Matter, Matthias S; Hilmenyuk, Tamara; Ochsenbein, Adrian (2012). CD27 signaling increases the frequency of regulatory T cells and promotes tumor growth. Cancer research, 72(14), pp. 3664-76. Birmingham, Ala.: American Association for Cancer Research AACR 10.1158/0008-5472.CAN-11-2791

2011

Matter, Matthias S; Hilmenyuk, Tamara; Claus, Christina; Marone, Romina; Schürch, Christian; Tinguely, Marianne; Terracciano, Luigi; Luther, Sanjiv A; Ochsenbein, Adrian (2011). Destruction of lymphoid organ architecture and hepatitis caused by CD4+ T cells. PLoS ONE, 6(9), e24772. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0024772

2010

Mumprecht, Sabine Barbara; Schürch, Christian; Scherrer, Sandro; Claus, Christina; Ochsenbein, Adrian (2010). Chronic myelogenous leukemia maintains specific CD8(+) T cells through IL-7 signaling. European journal of immunology, 40(10), pp. 2720-2730. Weinheim: Wiley-VCH 10.1002/eji.201040404

2009

Mumprecht, Sabine Barbara; Schürch, Christian; Schwaller, Juerg; Solenthaler, Max; Ochsenbein, Adrian F (2009). Programmed death 1 signaling on chronic myeloid leukemia-specific T cells results in T-cell exhaustion and disease progression. Blood, 114(8), pp. 1528-1536. Washington, D.C.: American Society of Hematology 10.1182/blood-2008-09-179697

Mumprecht, Sabine; Claus, Christina; Schürch, Christian; Pavelic, Viktor; Matter, Matthias S; Ochsenbein, Adrian F (2009). Defective homing and impaired induction of cytotoxic T cells by BCR/ABL-expressing dendritic cells. Blood, 113(19), pp. 4681-9. Washington, D.C.: American Society of Hematology 10.1182/blood-2008-05-156471

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