NaV1.5 and interacting proteins in human arrhythmogenic cardiomyopathy

Gillet, Ludovic; Shy, Diana Amy; Abriel, Hugues (2013). NaV1.5 and interacting proteins in human arrhythmogenic cardiomyopathy. Future cardiology, 9(4), pp. 467-470. Future Medicine Ltd 10.2217/fca.13.38

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Evaluation of: Noorman M, Hakim S, Kessler E et al. Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy. Heart Rhythm 10(3), 412-419 (2013). Arrhythmogenic cardiomyopathy (AC) is a heart muscle disease characterized by a progressive replacement of the ventricular myocardium with adipose and fibrous tissue. This disease is often associated with mutations in genes encoding desmosomal proteins in the majority of patients. Based on results obtained from recent experimental models, a disturbed distribution of gap junction proteins and cardiac sodium channels may also be observed in AC phenotypes, secondary to desmosomal dysfunction. The study from Noorman et al. examined heart sections from patients diagnosed with AC and performed immunohistochemical analyses of N-cadherin, PKP2, PKG, Cx43 and the cardiac sodium channel NaV1.5. Altered expression/distribution of Cx43, PKG and NaV1.5 was found in most cases of patients with AC. The altered expression and/or distribution of NaV1.5 channels in AC hearts may play a mechanistic role in the arrhythmias leading to sudden cardiac death in AC patients. Thus, NaV1.5 should be considered as a supplemental element in the evaluation of risk stratification and management strategies. However, additional experiments are required to clearly understand the mechanisms leading to AC phenotypes.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Ionenkanalkrankheiten
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Ionenkanalkrankheiten

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)

UniBE Contributor:

Gillet, Ludovic; Shy, Diana Amy and Abriel, Hugues

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1744-8298

Publisher:

Future Medicine Ltd

Language:

English

Submitter:

Verena de Serra Frazao-Bill

Date Deposited:

24 Jun 2014 14:37

Last Modified:

16 Sep 2014 17:04

Publisher DOI:

10.2217/fca.13.38

PubMed ID:

23834686

URI:

https://boris.unibe.ch/id/eprint/43784

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