Emergence of extensively drug-resistant Haemophilus parainfluenzae in Switzerland

Tinguely, Regula; Seiffert, Salome Nadja; Furrer, Hansjakob; Perreten, Vincent; Droz, Sara Christine; Endimiani, Andrea (2013). Emergence of extensively drug-resistant Haemophilus parainfluenzae in Switzerland. Antimicrobial agents and chemotherapy, 57(6), pp. 2867-2869. American Society for Microbiology 10.1128/AAC.00221-13

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Two homosexual men were colonized in the urethra with Haemophilus parainfluenzae nonsusceptible to ampicillin (MIC, 8 μg/ml), amoxicillin-clavulanate (MIC, 4 μg/ml), cefotaxime (MIC, 1.5 μg/ml), cefepime (MIC, 3 μg/ml), meropenem (MIC, 0.5 μg/ml), cefuroxime, azithromycin, ciprofloxacin, tetracycline, and chloramphenicol (all MICs, ≥ 32 μg/ml). Repetitive extragenic palindromic PCR (rep-PCR) showed that the strains were indistinguishable. The isolates had amino acid substitutions in PBP3, L4, GyrA, and ParC and possessed Mef(A), Tet(M), and CatS resistance mechanisms. This is the first report of extensively drug-resistant (XDR) H. parainfluenzae.

Item Type:	Journal Article (Original Article)
Division/Institute:	05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology
UniBE Contributor:	Seiffert, Salome Nadja, Furrer, Hansjakob, Perreten, Vincent, Droz, Sara Christine, Endimiani, Andrea
Subjects:	500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health 600 Technology > 630 Agriculture
ISSN:	0066-4804
Publisher:	American Society for Microbiology
Language:	English
Submitter:	Susanne Portner
Date Deposited:	21 Mar 2014 11:42
Last Modified:	05 Dec 2022 14:29
Publisher DOI:	10.1128/AAC.00221-13
PubMed ID:	23545526
URI:	https://boris.unibe.ch/id/eprint/43837