Abdel-Mohsen, Mohamed; Deng, Xutao; Liegler, Teri; Guatelli, John C.; Salama, Mohamed S.; Ghanem, Hussam El-din A; Rauch, Andri; Ledergerber, Bruno; Deeks, Steven G.; Günthard, Huldrych F.; Wong, Jospeh K.; Pillai, Satish K. (2014). Effects of Alpha Interferon Treatment on Intrinsic Anti-HIV-1 Immunity In Vivo. Journal of virology, 88(1), pp. 763-767. American Society for Microbiology 10.1128/JVI.02687-13
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Alpha interferon (IFN-α) suppresses human immunodeficiency virus type 1 (HIV-1) replication in vitro by inducing cell-intrinsic retroviral restriction mechanisms. We investigated the effects of IFN-α/ribavirin (IFN-α/riba) treatment on 34 anti-HIV-1 restriction factors in vivo. Expression of several anti-HIV-1 restriction factors was significantly induced by IFN-α/riba in HIV/hepatitis C virus (HCV)-coinfected individuals. Fold induction of cumulative restriction factor expression in CD4+ T cells was significantly correlated with viral load reduction during IFN-α/riba treatment (r2 = 0.649; P < 0.016). Exogenous IFN-α induces supraphysiologic restriction factor expression associated with a pronounced decrease in HIV-1 viremia.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology |
UniBE Contributor: |
Rauch, Andri |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0022-538X |
Publisher: |
American Society for Microbiology |
Language: |
English |
Submitter: |
Annelies Luginbühl |
Date Deposited: |
21 Mar 2014 16:30 |
Last Modified: |
05 Dec 2022 14:30 |
Publisher DOI: |
10.1128/JVI.02687-13 |
PubMed ID: |
24155399 |
BORIS DOI: |
10.7892/boris.44800 |
URI: |
https://boris.unibe.ch/id/eprint/44800 |
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