Nuclear organization in the nematode C. elegans.

Sharma, Rahul; Meister, Pierre (2013). Nuclear organization in the nematode C. elegans. Current opinion in cell biology, 25(3), pp. 395-402. Elsevier 10.1016/j.ceb.2013.02.002

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With its invariant cell lineage, easy genetics and small genome, the nematode Caenorhabditis elegans has emerged as one of the prime models in developmental biology over the last 50 years. Surprisingly however, until a decade ago very little was known about nuclear organization in worms, even though it is an ideal model system to explore the link between nuclear organization and cell fate determination. Here, we review the latest findings that exploit the repertoire of genetic tools developed in worms, leading to the identification of important sequences and signals governing the changes in chromatin tridimensional architecture. We also highlight parallels and differences to other model systems.

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