Small ruminant lentivirus genotype B and E interaction: evidences on the role of Roccaverano strain on reducing proviral load of the challenging CAEV strain

Bertolotti, Luigi; Reina, Ramsés; Mazzei, Maurizio; Preziuso, Silvia; Camero, Michele; Carrozza, Maria Luisa; Cavalli, Alessandra; Juganaru, Magda; Profiti, Margherita; De Meneghi, Daniele; Perona, Giovanni; Renzoni, Giacomo; Tursi, Massimiliano; Bertoni, Giuseppe; Rosati, Sergio (2013). Small ruminant lentivirus genotype B and E interaction: evidences on the role of Roccaverano strain on reducing proviral load of the challenging CAEV strain. Veterinary microbiology, 163(1-2), pp. 33-41. Elsevier 10.1016/j.vetmic.2012.12.004

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Live attenuated vaccines provide the most consistent protective immunity in experimental models of lentivirus infections. In this study we tested the hypothesis that animals infected with a naturally attenuated small ruminant lentivirus field strain of genotype E may control a challenge infection with a virulent strain of the caprine arthritis encephalitis virus (CAEV-CO). Within genotype E, Roccaverano strain has been described as attenuated since decreased arthritic pathological indexes were recorded in Roccaverano-infected animals compared to animals of the same breed infected with genotype B strains. Moreover, under natural conditions, animals double-infected with genotypes B and E appear less prone to develop SRLV-related disease, leading to a putative protective role of Roccaverano strain. Here we present evidence that goats experimentally infected with the avirulent genotype E SRLV-Roccaverano strain control the proviral load of a pathogenic challenge virus (CAEV-CO strain) more efficiently than naïve animals and appear to limit the spread of histological lesions to the contralateral joints.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Bertoni, Giuseppe

Subjects:

600 Technology > 630 Agriculture

ISSN:

0378-1135

Publisher:

Elsevier

Language:

English

Submitter:

Susanne Portner

Date Deposited:

28 Jul 2014 11:08

Last Modified:

14 Oct 2015 11:34

Publisher DOI:

10.1016/j.vetmic.2012.12.004

PubMed ID:

23290119

Uncontrolled Keywords:

Small ruminant lentivirus, Genotype E, Roccaverano, Experimental infection, Immunization strategy

BORIS DOI:

10.7892/boris.45936

URI:

https://boris.unibe.ch/id/eprint/45936

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