Inheritance of equine sarcoid disease in Franches-Montagnes horses.

Christen, Garance Anne; Gerber, Vinzenz; Dolf, Gaudenz; Burger, Dominik; Koch, Christoph (2014). Inheritance of equine sarcoid disease in Franches-Montagnes horses. Veterinary journal, 199(1), pp. 68-71. Elsevier 10.1016/j.tvjl.2013.09.053

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The mode of inheritance for susceptibility to equine sarcoid disease (ES) remains unknown. The objectives of this study were to analyse a large sample of the Franches-Montagnes (FM) horse population and investigate the heritability and mode of inheritance for susceptibility to ES. Horses were clinically examined for the presence of sarcoid tumours. A standardized examination protocol and client questionnaire were used and a pedigree- and subsequent segregation-analysis for the ES trait performed. To investigate the mode of inheritance, five models were evaluated and compared in a hierarchical way. The analyses reveal that variation in susceptibility to ES is best explained by a model incorporating polygenic variation. The possible effect of a major gene, such as specific equine leukocyte antigen alleles, is unlikely, but cannot be ruled-out entirely. The heritability of the phenotype on the observation scale for the trait 'affected with ES' was estimated to be 8%. A corrected value for the heritability on a liability scale was estimated at 21% and it is therefore possible to estimate breeding values for ES. The arguments against the practical implementation of an estimated breeding value in a multifactorial condition like ES are discussed.

Item Type:

Journal Article (Original Article)


05 Veterinary Medicine > Research Foci > DermFocus
05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > ISME Equine Clinic Bern > ISME Equine Clinic, Internal medicine
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics

UniBE Contributor:

Christen, Garance Anne, Gerber, Vinzenz, Dolf, Gaudenz, Burger, Dominik Cyrill, Koch, Christoph


600 Technology > 630 Agriculture
500 Science > 590 Animals (Zoology)








Susanne Portner

Date Deposited:

04 Sep 2014 09:00

Last Modified:

02 Mar 2023 23:24

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Breeding, Heritability, Horse, Sarcoid, Segregation analysis




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