Christen, Garance Anne; Gerber, Vinzenz; Dolf, Gaudenz; Burger, Dominik; Koch, Christoph (2014). Inheritance of equine sarcoid disease in Franches-Montagnes horses. Veterinary journal, 199(1), pp. 68-71. Elsevier 10.1016/j.tvjl.2013.09.053
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The mode of inheritance for susceptibility to equine sarcoid disease (ES) remains unknown. The objectives of this study were to analyse a large sample of the Franches-Montagnes (FM) horse population and investigate the heritability and mode of inheritance for susceptibility to ES. Horses were clinically examined for the presence of sarcoid tumours. A standardized examination protocol and client questionnaire were used and a pedigree- and subsequent segregation-analysis for the ES trait performed. To investigate the mode of inheritance, five models were evaluated and compared in a hierarchical way. The analyses reveal that variation in susceptibility to ES is best explained by a model incorporating polygenic variation. The possible effect of a major gene, such as specific equine leukocyte antigen alleles, is unlikely, but cannot be ruled-out entirely. The heritability of the phenotype on the observation scale for the trait 'affected with ES' was estimated to be 8%. A corrected value for the heritability on a liability scale was estimated at 21% and it is therefore possible to estimate breeding values for ES. The arguments against the practical implementation of an estimated breeding value in a multifactorial condition like ES are discussed.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
05 Veterinary Medicine > Research Foci > DermFocus 05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Equine Clinic 05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics |
UniBE Contributor: |
Christen, Garance Anne; Gerber, Vinzenz; Dolf, Gaudenz; Burger, Dominik and Koch, Christoph |
Subjects: |
600 Technology > 630 Agriculture 500 Science > 590 Animals (Zoology) |
ISSN: |
1090-0233 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Susanne Portner |
Date Deposited: |
04 Sep 2014 09:00 |
Last Modified: |
02 Oct 2018 15:48 |
Publisher DOI: |
10.1016/j.tvjl.2013.09.053 |
PubMed ID: |
24152383 |
Uncontrolled Keywords: |
Breeding, Heritability, Horse, Sarcoid, Segregation analysis |
BORIS DOI: |
10.7892/boris.46023 |
URI: |
https://boris.unibe.ch/id/eprint/46023 |