Penetrating or stricturing diseases are the major determinants of time to first and repeat resection surgery in Crohn's disease

Pittet, Valerie; Rogler, Gerhard; Michetti, Pierre; Fournier, Nicolas; Vader, John-Paul; Schoepfer, Alain; Mottet, Christian; Burnand, Bernard; Froehlich, Florian; Müller, Christoph; Swiss IBD Cohort Study Group, (2013). Penetrating or stricturing diseases are the major determinants of time to first and repeat resection surgery in Crohn's disease. Digestion, 87(3), pp. 212-21. Karger 10.1159/000350954

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BACKGROUND About 80% of patients with Crohn's disease (CD) require bowel resection and up to 65% will undergo a second resection within 10 years. This study reports clinical risk factors for resection surgery (RS) and repeat RS. METHODS Retrospective cohort study, using data from patients included in the Swiss Inflammatory Bowel Disease Cohort. Cox regression analyses were performed to estimate rates of initial and repeated RS. RESULTS Out of 1,138 CD cohort patients, 417 (36.6%) had already undergone RS at the time of inclusion. Kaplan-Meier curves showed that the probability of being free of RS was 65% after 10 years, 42% after 20 years, and 23% after 40 years. Perianal involvement (PA) did not modify this probability to a significant extent. The main adjusted risk factors for RS were smoking at diagnosis (hazard ratio (HR) = 1.33; p = 0.006), stricturing with vs. without PA (HR = 4.91 vs. 4.11; p < 0.001) or penetrating disease with vs. without PA (HR = 3.53 vs. 4.58; p < 0.001). The risk factor for repeat RS was penetrating disease with vs. without PA (HR = 3.17 vs. 2.24; p < 0.05). CONCLUSION The risk of RS was confirmed to be very high for CD in our cohort. Smoking status at diagnosis, but mostly penetrating and stricturing diseases increase the risk of RS.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Müller, Christoph

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0012-2823

Publisher:

Karger

Language:

English

Submitter:

Andrea Arnold

Date Deposited:

12 Jun 2014 09:04

Last Modified:

10 Sep 2015 09:34

Publisher DOI:

10.1159/000350954

PubMed ID:

23711401

Uncontrolled Keywords:

Crohn’s disease, Epidemiology, Surgery for IBD

URI:

https://boris.unibe.ch/id/eprint/46038

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