Anaplastic oligodendroglioma arising from the brain stem and featuring 1p/19q co-deletion

Hewer, Ekkehard; Beck, Jürgen; Vassella, Erik; Vajtai, Istvan (2014). Anaplastic oligodendroglioma arising from the brain stem and featuring 1p/19q co-deletion. Neuropathology, 34(1), pp. 32-38. Wiley 10.1111/neup.12043

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With respect to localization, oligodendrogliomas are characterized by a marked preponderance of the cerebral hemispheres. Outside these typical sites, any tumor histopathologically reminiscent of oligodendroglioma a priori is likely to represent one of its morphological mimics, including clear cell ependymoma, neurocytoma, pilocytic astrocytoma or glioneuronal tumors. This is particularly relevant as several of the latter are in principle curable by surgery. Among extrahemispherical sites, bona fide oligodendroglioma - as characterized by loss of heterozygosity (LOH) of chromosome arms 1p and 19q - so far has not been documented to occur in the brain stem. Here, we report the case of a 55-year-old female patient with an anaplastic oligodendroglioma (WHO grade III) of the brain stem and cerebellum diagnosed by stereotactic biopsy and featuring combined LOH of 1p and 19q. A morphological peculiarity was a population of interspersed tumor giant cells, a phenomenon that has been referred to as polymorphous oligodendroglioma. Our findings confirm the notion that - although very infrequently - true oligodendrogliomas do occur in the infratentorial compartment.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Hewer, Ekkehard; Beck, Jürgen; Vassella, Erik and Vajtai, Istvan

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

0919-6544

Publisher:

Wiley

Language:

English

Submitter:

Andrea Arnold

Date Deposited:

02 Apr 2014 14:45

Last Modified:

10 Sep 2015 09:32

Publisher DOI:

10.1111/neup.12043

PubMed ID:

23711170

Uncontrolled Keywords:

brain stem, cerebellum, differential diagnosis, loss of heterozygosity, oligodendroglioma

BORIS DOI:

10.7892/boris.46101

URI:

https://boris.unibe.ch/id/eprint/46101

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