A chromosomal region on ECA13 is associated with maxillary prognathism in horses.

Signer-Hasler, Heidi; Neuditschko, Markus; Koch, Christoph; Froidevaux, Sylvie Marie; Flury, Christine; Burger, Dominik; Leeb, Tosso; Rieder, Stefan (2014). A chromosomal region on ECA13 is associated with maxillary prognathism in horses. PLoS ONE, 9(1), e86607. Public Library of Science 10.1371/journal.pone.0086607

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Hereditary variations in head morphology and head malformations are known in many species. The most common variation encountered in horses is maxillary prognathism. Prognathism and brachygnathism are syndromes of the upper and lower jaw, respectively. The resulting malocclusion can negatively affect teeth wear, and is considered a non-desirable trait in breeding programs. We performed a case-control analysis for maxillary prognathism in horses using 96 cases and 763 controls. All horses had been previously genotyped with a commercially available 50 k SNP array. We analyzed the data with a mixed-model considering the genomic relationships in order to account for population stratification. Two SNPs within a region on the distal end of chromosome ECA 13 reached the Bonferroni corrected genome-wide significance level. There is no known prognathism candidate gene located within this region. Therefore, our findings in the horse offer the possibility of identifying a novel gene involved in the complex genetics of prognathism that might also be relevant for humans and other livestock species.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Equine Clinic
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics

UniBE Contributor:

Koch, Christoph; Froidevaux, Sylvie Marie; Burger, Dominik and Leeb, Tosso

Subjects:

600 Technology > 630 Agriculture
500 Science > 590 Animals (Zoology)

ISSN:

1932-6203

Publisher:

Public Library of Science

Language:

English

Submitter:

Susanne Portner

Date Deposited:

04 Sep 2014 10:01

Last Modified:

09 Dec 2014 21:34

Publisher DOI:

10.1371/journal.pone.0086607

PubMed ID:

24466169

BORIS DOI:

10.7892/boris.46112

URI:

https://boris.unibe.ch/id/eprint/46112

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