The growing galectin network in colon cancer and clinical relevance of cytoplasmic galectin-3 reactivity

Dawson, Heather; André, Sabine; Karamitopoulou, Evanthia; Zlobec, Inti; Gabius, Hans-Joachim (2013). The growing galectin network in colon cancer and clinical relevance of cytoplasmic galectin-3 reactivity. Anticancer research, 33(8), pp. 3053-3059. International Inst. of Anticancer Research

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BACKGROUND/AIM Human lectins translate sugar-encoded signals of cell surface glycoconjugates into biological effects, and this is what is known for the adhesion/growth-regulatory galectins. In addition, the multifunctional members of this group can be intracellular, binding to distinct proteins. The presence of galectins and galectin reactivity were exemplarily studied in the present article. MATERIALS AND METHODS We combined immuno- and lectin histochemical monitoring in colon cancer on tissue arrays. RESULTS Intracellular presence of galectins-7 and -9 in colon cancer is detected, extending the previously known set of five expressed lectins this tumor type. The assumed significance of intracellular galectin presence, e.g. for an interplay with BCL2, β-catenin, oncogenic KRAS or synexin, is underscored by respective staining with labeled galectin-3. Statistical significance was obtained for galectin-3 staining with respect to tumor differentiation (p=0.0376), lymph node metastasis (p=0.0069) and lymphatic invasion (p=0.0156). Survival was correlated to staining, galectin-3 reactivity indicating a favorable prognosis (p=0.0183), albeit not as an independent marker. No correlation to KRAS/BRAF status was detected. CONCLUSION These results encourage further testing of labeled human galectins as probes and immunohistochemical fingerprinting instead of measuring single or few activities, in colon cancer and other tumor types.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Dawson, Heather; Karamitopoulou, Evanthia and Zlobec, Inti

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0250-7005

Publisher:

International Inst. of Anticancer Research

Language:

English

Submitter:

Andrea Arnold

Date Deposited:

02 Apr 2014 16:31

Last Modified:

13 Feb 2017 10:03

PubMed ID:

23898060

Uncontrolled Keywords:

Apoptosis, glycosylation, invasion, lectin, prognosis

URI:

https://boris.unibe.ch/id/eprint/46158

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