Ceschi, Alessandro; Berger, David; Dickenmann, Michael; Bodmer, Michael (2013). Pharmacokinetics of meprobamate in overdose treated with continuous venovenous hemodiafiltration (CVVHDF). Hemodialysis International, 17(4), pp. 656-659. Wiley-Blackwell 10.1111/hdi.12047
Full text not available from this repository.We report a case of massive suicidal overdose of meprobamate leading to cardiovascular collapse, respiratory failure, and severe central nervous system depression. We observed first-order elimination kinetics despite significant overdose, and demonstrated effectiveness of continuous venovenous hemodiafiltration (CVVHDF) for extracorporeal removal of meprobamate in this patient. Total body clearance was calculated to be 87 mL/minute, with 64 mL/minute (74%) due to CVVHDF. CVVHDF was stopped after 36 hours, and the patient made an uneventful recovery.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine 04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care 04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine |
UniBE Contributor: |
Berger, David, Bodmer, Michael |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1542-4758, 1492-7535 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Patricia Rajaonina |
Date Deposited: |
28 Mar 2014 15:38 |
Last Modified: |
05 Dec 2022 14:31 |
Publisher DOI: |
10.1111/hdi.12047 |
PubMed ID: |
23615322 |
Uncontrolled Keywords: |
CVVHDF, Poisoning, hemodiafiltration, meprobamate |
URI: |
https://boris.unibe.ch/id/eprint/47407 |
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