Investigating the interaction of cellulose nanofibers derived from cotton with a sophisticated 3D human lung cell coculture

Clift, Martin J D; Foster, E Johan; Vanhecke, Dimitri; Studer, Daniel; Wick, Peter; Gehr, Peter; Rothen-Rutishauser, Barbara; Weder, Christoph (2011). Investigating the interaction of cellulose nanofibers derived from cotton with a sophisticated 3D human lung cell coculture. Biomacromolecules, 12(10), pp. 3666-73. Washington, D.C.: American Chemical Society 10.1021/bm200865j

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Cellulose nanofibers are an attractive component of a broad range of nanomaterials. Their intriguing mechanical properties and low cost, as well as the renewable nature of cellulose make them an appealing alternative to carbon nanotubes (CNTs), which may pose a considerable health risk when inhaled. Little is known, however, concerning the potential toxicity of aerosolized cellulose nanofibers. Using a 3D in vitro triple cell coculture model of the human epithelial airway barrier, it was observed that cellulose nanofibers isolated from cotton (CCN) elicited a significantly (p < 0.05) lower cytotoxicity and (pro-)inflammatory response than multiwalled CNTs (MWCNTs) and crocidolite asbestos fibers (CAFs). Electron tomography analysis also revealed that the intracellular localization of CCNs is different from that of both MWCNTs and CAFs, indicating fundamental differences between each different nanofibre type in their interaction with the human lung cell coculture. Thus, the data shown in the present study highlights that not only the length and stiffness determine the potential detrimental (biological) effects of any nanofiber, but that the material used can significantly affect nanofiber-cell interactions.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology

UniBE Contributor:

Vanhecke, Dimitri; Studer, Daniel Franz; Gehr, Peter and Rothen-Rutishauser, Barbara

ISSN:

1525-7797

Publisher:

American Chemical Society

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:17

Last Modified:

17 Mar 2015 19:22

Publisher DOI:

10.1021/bm200865j

PubMed ID:

21846085

Web of Science ID:

000295602600034

URI:

https://boris.unibe.ch/id/eprint/5138 (FactScience: 209856)

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