Estrogen receptor- but not - or GPER inhibits high glucose-induced human VSMC proliferation: potential role of ROS and ERK

Ortmann, Jana; Veit, Martha; Zingg, Sandra; Di Santo, Stefano; Traupe, Tobias; Yang, Zijiang; Völzmann, Jan; Dubey, Raghvendra K; Christen, Stephan; Baumgartner, Iris (2011). Estrogen receptor- but not - or GPER inhibits high glucose-induced human VSMC proliferation: potential role of ROS and ERK. Journal of clinical endocrinology and metabolism, 96(1), pp. 220-8. Chevy Chase, Md.: Endocrine Society 10.1210/jc.2010-0943

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The decreased incidence of cardiovascular disease in premenopausal women has been attributed, at least partially, to protective effects of estrogens. However, premenopausal women with diabetes mellitus are no longer selectively protected. High-glucose (HG) conditions have previously been shown to abolish the antimitogenic effects of 17β-estradiol (E(2)) in vascular smooth muscle cells (VSMCs).

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology

UniBE Contributor:

Di Santo, Stefano; Traupe, Tobias; Yang, Zijiang; Christen, Stephan and Baumgartner, Iris

ISSN:

0021-972X

Publisher:

Endocrine Society

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:08

Last Modified:

06 Dec 2013 13:19

Publisher DOI:

10.1210/jc.2010-0943

PubMed ID:

20962025

Web of Science ID:

000286502900032

URI:

https://boris.unibe.ch/id/eprint/516 (FactScience: 199640)

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