Dexamethasone aggravates hippocampal apoptosis and learning deficiency in pneumococcal meningitis in infant rats.

Leib, Stephen; Heimgartner, Chris; Bifrare, Yoeng-Delphine; Loeffler, Jutta M; Täuber, Martin G. (2003). Dexamethasone aggravates hippocampal apoptosis and learning deficiency in pneumococcal meningitis in infant rats. Pediatric research, 54(3), pp. 353-357. Nature Publishing Group 10.1203/01.PDR.0000079185.67878.72

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In an infant rat model of pneumococcal meningitis the effect of dexamethasone on neuronal injury in the hippocampus and on learning disability after recovery from the disease was examined. Treatment with dexamethasone or vehicle was started 18 h after infection, concomitant with antibiotics. Neuronal apoptosis in the hippocampal dentate gyrus 34 h after infection was significantly aggravated by dexamethasone treatment compared with vehicle controls (p = 0.02). Three weeks after acute pneumococcal meningitis, learning capacity of animals was assessed in the Morris water maze. The results showed a significantly impaired learning performance of infected animals treated with dexamethasone compared with vehicle controls (p = 0.01). Dexamethasone had no effect on hippocampal injury or learning in uninfected controls. Thus, dexamethasone as adjuvant therapy increased hippocampal cell injury and reduced learning capacity in this model of pneumococcal meningitis in infant rats.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Leib, Stephen and Täuber, Martin G.

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0031-3998

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Stephen Leib

Date Deposited:

01 Sep 2014 07:57

Last Modified:

08 Jul 2015 07:54

Publisher DOI:

10.1203/01.PDR.0000079185.67878.72

PubMed ID:

12788989

BORIS DOI:

10.7892/boris.52739

URI:

https://boris.unibe.ch/id/eprint/52739

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