[Nocardia cyriacigeorgici: First report of invasive human infection]

Fux, C; Bodmer, Thomas; Ziswiler, Hans Rudolf; Leib, Stephen (2003). [Nocardia cyriacigeorgici: First report of invasive human infection]. Deutsche medizinische Wochenschrift, 128(19), pp. 1038-1041. Thieme 10.1055/s-2003-39102

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BACKGROUND Diagnostic laboratories increasingly offer bacterial identification to the species level. The 17 nocardia species known to date differ in their clinical presentation, antibiotic resistance patterns and geographic distribution. The discovery of a new species with pathogenicity for humans calls for the characterization of its clinical and epidemiological properties. PATIENTS AND METHODS Nocardia isolated from multifocal brain abscesses of an immunocompromised patient were further identified by the analysis of their cellular fatty acids and sequencing of the 16S ribosomal DNA. Quantitative antibiotic resistance testing was performed with E-tests. RESULTS The 16S ribosomal DNA analysis showed a 99 % homology to Nocardia cyriacigeorgici. This is the first report of this species as an invasive human pathogen. N. cyriacigeorgici was found susceptible for meropenem, amikacin, ceftriaxon and cotrimoxazole. The combination of surgical drainage and antibiotic treatment for 13 months was curative. CONCLUSIONS N. cyriacigeorgici has the potential to cause invasive infections at least in immunocompromised patients. Comparing clinical and in vitro characteristics with N. asteroides, the main causative agent of nocardial infections in Europe, we found no clinically relevant differences.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Bodmer, Thomas; Ziswiler, Hans Rudolf and Leib, Stephen

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

0012-0472

Publisher:

Thieme

Language:

German

Submitter:

Stephen Leib

Date Deposited:

01 Sep 2014 08:16

Last Modified:

08 Jul 2015 07:58

Publisher DOI:

10.1055/s-2003-39102

PubMed ID:

12736853

BORIS DOI:

10.7892/boris.52744

URI:

https://boris.unibe.ch/id/eprint/52744

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