Williams, Paul L; Leib, Stephen; Kamberi, Perparim; Leppert, David; Sobel, Raymond A; Bifrare, Yoeng-Delphine; Clemons, Karl V; Stevens, David A (2002). Levels of matrix metalloproteinase-9 within cerebrospinal fluid in a rabbit model of coccidioidal meningitis and vasculitis. Journal of infectious diseases, 186(11), pp. 1692-1695. The University of Chicago Press 10.1086/345365
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Levels of Matrix Metalloproteinase–9 within Cerebrospinal Fluid in a Rabbit.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (90kB) |
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Matrix metalloproteinase (MMP)-9 is produced by the central nervous system and inflammatory cells in a variety of inflammatory conditions in both animals and humans. MMP-9 promotes inflammation, breakdown of the blood-brain barrier, and vasculitis. Because vasculitis is seen frequently in patients with coccidioidal meningitis (CM), this study evaluated the presence of MMP-9 within the cerebrospinal fluid (CSF) of rabbits infected intracisternally with Coccidioides immitis arthroconidia. Infected rabbits demonstrated systemic and neurological sequelae to infection, including CSF pleocytosis. Levels of MMP-9 within CSF were assayed by use of zymography and compared with MMP-2 levels, which served as an internal control. Elevated levels of MMP-9 were detectable by day 3, continued to increase through day 10, and declined by day 15 after infection. MMP-9 may contribute to inflammation and vasculitis in this animal model. Future work can focus on evaluation of MMP inhibitors, to gain a better perspective of the role of this MMP in CM.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases |
UniBE Contributor: |
Leib, Stephen |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
0022-1899 |
Publisher: |
The University of Chicago Press |
Language: |
English |
Submitter: |
Stephen Leib |
Date Deposited: |
01 Sep 2014 09:21 |
Last Modified: |
05 Dec 2022 14:34 |
Publisher DOI: |
10.1086/345365 |
PubMed ID: |
12447750 |
BORIS DOI: |
10.7892/boris.52749 |
URI: |
https://boris.unibe.ch/id/eprint/52749 |
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