Alphaviral cytotoxicity and its implication in vector development

Rhême, Céline; Ehrengruber, Markus U; Grandgirard, Denis (2005). Alphaviral cytotoxicity and its implication in vector development. Experimental physiology, 90(1), pp. 45-52. Blackwell 10.1113/expphysiol.2004.028142

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A great variety of viruses have been engineered to serve as expression vectors. Among them, the alphaviruses Semliki Forest virus and Sindbis virus represent promising tools for heterologous gene expression in a wide variety of host cells. Several applications have already been described in neurobiological studies, in gene therapy, for vaccine development and in cancer therapy. Both viruses trigger stress pathways in the cells they infect, sometimes culminating in the death of the host. This inherent property is either an advantage or a drawback, depending on the type of application. This review covers the development and applications of alphavirus vectors and, as our work has been mainly with Semliki Forest virus, we have focused on this virus with special emphasis on how the understanding of Semliki Forest virus cytotoxicity enables it to be manipulated and used.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research

UniBE Contributor:

Grandgirard, Denis

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0958-0670

Publisher:

Blackwell

Language:

English

Submitter:

Denis Grandgirard

Date Deposited:

25 Sep 2014 14:44

Last Modified:

25 Sep 2014 14:44

Publisher DOI:

10.1113/expphysiol.2004.028142

PubMed ID:

15542620

URI:

https://boris.unibe.ch/id/eprint/52807

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