Oxidative Damage on RNA Nucleobases

Küpfer, Pascal A.; Leumann, Christian J. (2014). Oxidative Damage on RNA Nucleobases. In: Erdmann, Volker A.; Markiewicz, Wojciech T.; Barciszewski, Jan (eds.) Chemical Biology of Nucleic Acids. RNA Technologies (pp. 75-94). Heidelberg: Springer 10.1007/978-3-642-54452-1_5

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Oxidatively damaged RNA has recently gathered more attention and has been closely related to different neurodegenerative diseases. The principles of oxidative stress and its influence on nucleic acids are reported. In contrast to DNA oxidative lesions of RNA have been scarcely described in the literature so far. These known stable RNA base modifications which arise under oxidative stress are reviewed here with regard to their biophysical properties and their potential mutagenicity. Furthermore the possible mechanisms of how cells deal with oxidized RNA are discussed. Posttranscriptional RNA modifications and the oxidation of RNA as an early event in several neurodegenerative diseases are not in the scope of this review.

Item Type:

Book Section (Book Chapter)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Küpfer, Pascal and Leumann, Christian

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISBN:

978-3-642-54451-4

Series:

RNA Technologies

Publisher:

Springer

Language:

English

Submitter:

Christian Leumann

Date Deposited:

04 Jun 2014 13:29

Last Modified:

08 Dec 2014 05:47

Publisher DOI:

10.1007/978-3-642-54452-1_5

Uncontrolled Keywords:

RNA oxidation, Reactive oxygen species, Reverse transcription, 8-Oxo-guanosine, Modified RNA

BORIS DOI:

10.7892/boris.52983

URI:

https://boris.unibe.ch/id/eprint/52983

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