Intensive care sedation: the past, present and the future

Shehabi, Yahya; Bellomo, Rinaldo; Mehta, Sangeeta; Riker, Richard; Takala, Jukka (2013). Intensive care sedation: the past, present and the future. Critical care, 17(3), p. 322. BioMed Central 10.1186/cc12679

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Despite the universal prescription of sedative drugs in the intensive care unit (ICU), current practice is not guided by high-level evidence. Landmark sedation trials have made significant contributions to our understanding of the problems associated with ICU sedation and have promoted changes to current practice. We identified challenges and limitations of clinical trials which reduced the generalizability and the universal adoption of key interventions. We present an international perspective regarding current sedation practice and a blueprint for future research, which seeks to avoid known limitations and generate much-needed high-level evidence to better guide clinicians' management and therapeutic choices of sedative agents.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care

UniBE Contributor:

Takala, Jukka

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1364-8535

Publisher:

BioMed Central

Language:

English

Submitter:

Alessandra Angelini

Date Deposited:

04 Jul 2014 08:26

Last Modified:

06 Dec 2014 00:35

Publisher DOI:

10.1186/cc12679

PubMed ID:

23758942

BORIS DOI:

10.7892/boris.54336

URI:

https://boris.unibe.ch/id/eprint/54336

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