Lange, Annika; Gustke, Heike; Glassmeier, Günter; Heine, Markus; Zangemeister-Wittke, Uwe; Schwarz, Jürgen R; Schumacher, Udo; Lange, Tobias (2011). Neuronal differentiation by indomethacin and IBMX inhibits proliferation of small cell lung cancer cells in vitro. Lung cancer, 74(2), pp. 178-87. Amsterdam: Elsevier 10.1016/j.lungcan.2011.03.017
Full text not available from this repository.Small cell lung cancer (SCLC) is one of the most aggressive malignancies implying a very poor prognosis for patients even under therapy. Since it is known that SCLC cells exhibit neurone-like characteristics, we investigated whether a neuronal induction medium (NID) consisting of indomethacin (200 ?M), 3-isobutyl-1-methylxanthine (IBMX, 500 ?M) and insulin (5 ?g/ml) induces neuronal differentiation and by this reduces malignancy of SCLC in vitro.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology |
UniBE Contributor: |
Zangemeister-Wittke, Uwe |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0169-5002 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:18 |
Last Modified: |
05 Dec 2022 14:04 |
Publisher DOI: |
10.1016/j.lungcan.2011.03.017 |
PubMed ID: |
21511354 |
Web of Science ID: |
000296684300005 |
URI: |
https://boris.unibe.ch/id/eprint/5468 (FactScience: 210215) |
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