High CD10 expression predicts favorable outcome in surgically treated lymph node-positive bladder cancer patients

Seiler, Roland; von Gunten, Michael; Thalmann, George N; Fleischmann, Achim (2012). High CD10 expression predicts favorable outcome in surgically treated lymph node-positive bladder cancer patients. Human pathology, 43(2), pp. 269-75. Philadelphia, Pa.: Elsevier 10.1016/j.humpath.2011.04.030

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CD10 predicts survival in different cancers. The prognostic significance in bladder cancer still has to be documented. One hundred fifty lymph node-positive bladder cancer patients were treated by cystectomy and standardized pelvic lymphadenectomy in curative intent. CD10 expression was evaluated in tissue microarrays (TMAs) constructed from histopathological normal urothelium, primary tumor (tumor center and invasion front), and corresponding lymph node metastases and correlated with tumor characteristics (stage, extracapsular extension, number, and total diameter of metastases) and survival. CD10 expression was successively lost from normal urothelium to primary tumor to metastases (P < .05) and decreased from the tumor center to the invasion front (P < .002). High CD10 expression in tumor center or invasion front (P < .05) but not in the metastases predicted favorable outcome; the prognostic information in the tumor center was independent from tumor stage and lymph node parameters. High CD10 expression level was not associated with specific tumor characteristics. A well-defined sampling strategy for TMAs allows detection of specific biomarker expression patterns and may generate prognostic information inherent in particular tumor areas. The favorable outcome in bladder cancer patients with high CD10 expression might suggest a tumor suppressive function of CD10.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology 04 Faculty of Medicine > Service Sector > Institute of Pathology
UniBE Contributor:	Seiler-Blarer, Roland, Thalmann, George, Fleischmann, Achim
ISSN:	0046-8177
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:18
Last Modified:	02 Mar 2023 23:20
Publisher DOI:	10.1016/j.humpath.2011.04.030
PubMed ID:	21835428
Web of Science ID:	000299766600015
URI:	https://boris.unibe.ch/id/eprint/5477 (FactScience: 210224)