High CD10 expression predicts favorable outcome in surgically treated lymph node-positive bladder cancer patients

Seiler, Roland; von Gunten, Michael; Thalmann, George N; Fleischmann, Achim (2012). High CD10 expression predicts favorable outcome in surgically treated lymph node-positive bladder cancer patients. Human pathology, 43(2), pp. 269-75. Philadelphia, Pa.: Elsevier 10.1016/j.humpath.2011.04.030

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CD10 predicts survival in different cancers. The prognostic significance in bladder cancer still has to be documented. One hundred fifty lymph node-positive bladder cancer patients were treated by cystectomy and standardized pelvic lymphadenectomy in curative intent. CD10 expression was evaluated in tissue microarrays (TMAs) constructed from histopathological normal urothelium, primary tumor (tumor center and invasion front), and corresponding lymph node metastases and correlated with tumor characteristics (stage, extracapsular extension, number, and total diameter of metastases) and survival. CD10 expression was successively lost from normal urothelium to primary tumor to metastases (P < .05) and decreased from the tumor center to the invasion front (P < .002). High CD10 expression in tumor center or invasion front (P < .05) but not in the metastases predicted favorable outcome; the prognostic information in the tumor center was independent from tumor stage and lymph node parameters. High CD10 expression level was not associated with specific tumor characteristics. A well-defined sampling strategy for TMAs allows detection of specific biomarker expression patterns and may generate prognostic information inherent in particular tumor areas. The favorable outcome in bladder cancer patients with high CD10 expression might suggest a tumor suppressive function of CD10.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Seiler, Roland; Thalmann, George and Fleischmann, Achim

ISSN:

0046-8177

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:18

Last Modified:

06 Dec 2013 13:25

Publisher DOI:

10.1016/j.humpath.2011.04.030

PubMed ID:

21835428

Web of Science ID:

000299766600015

URI:

https://boris.unibe.ch/id/eprint/5477 (FactScience: 210224)

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