Atypical presentation of Behçet's disease with central nervous system involvement successfully treated with infliximab

Studer, U; Ruehe, B; Waldegg, G; Vajtai, I; Escher, R; Aeberli, D (2012). Atypical presentation of Behçet's disease with central nervous system involvement successfully treated with infliximab. Rheumatology international, 32(5), pp. 1431-5. Berlin: Springer 10.1007/s00296-011-1915-x

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Central nervous system involvement is a rare and serious complication of Behçet's disease (BD). Herein, we describe a patient with an atypical central lesion, who experienced progressive hypesthesia of the right arm and sensory loss of the trigeminal nerve together with intense headache. A repeated biopsy was necessary to conclusively establish the diagnosis of BD. Therapy with infusions of infliximab led to a remarkable full remission. TNFα-blocking therapy was successfully replaced by azathioprine. The present well-illustrated case demonstrates the difficulty of establishing the diagnosis of BD with central nervous system involvement, the dramatic benefit of short given TNF-α-blocking agent, and the long-term remission with azathioprin.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology

UniBE Contributor:

Vajtai, Istvan and Aeberli, Daniel

ISSN:

0172-8172

Publisher:

Springer

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:18

Last Modified:

06 Dec 2013 13:26

Publisher DOI:

10.1007/s00296-011-1915-x

PubMed ID:

21445544

Web of Science ID:

000303434400053

URI:

https://boris.unibe.ch/id/eprint/5578 (FactScience: 210344)

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