Standard and higher doses of atropine in a canine model of pulseless electrical activity

DeBehnke, D J; Swart, G L; Spreng, David; Aufderheide, T P (1995). Standard and higher doses of atropine in a canine model of pulseless electrical activity. Academic emergency medicine, 2(12), pp. 1034-1041. Wiley 10.1111/j.1553-2712.1995.tb03145.x

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OBJECTIVE To determine whether standard or increased doses of atropine improve the return of spontaneous circulation (ROSC) rate in a canine model of pulseless electrical activity (PEA). METHODS A prospective, controlled, blinded laboratory investigation was performed using an asphyxial canine cardiac arrest model. After the production of asphyxial PEA, 75 dogs remained in untreated PEA for 10 minutes and then were randomized to receive placebo (group 1) or one of four doses of atropine (group 2, 0.04 mg/kg; group 3, 0.1 mg/kg; group 4, 0.2 mg/kg; group 5, 0.4 mg/kg). All the animals received mechanical external CPR and epinephrine (0.02 mg/kg every 3 minutes) throughout resuscitation. RESULTS The ROSC rates were not significantly different between the groups (group 1, 73%; group 2, 67%; group 3, 40%; group 4, 47%; group 5, 27%; p = 0.06). The heart rates and hemodynamics during resuscitation were not significantly different between the groups. CONCLUSION In this canine model of asphyxial PEA cardiac arrest, standard-dose atropine did not improve ROSC rates, compared with placebo. Increasing doses of atropine tended to decrease ROSC rates, compared with placebo and standard-dose atropine.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic > Small Animal Clinic, Surgery
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic

UniBE Contributor:

Spreng, David

Subjects:

500 Science
600 Technology > 630 Agriculture

ISSN:

1069-6563

Publisher:

Wiley

Language:

English

Submitter:

Simone Forterre

Date Deposited:

17 Sep 2014 12:20

Last Modified:

17 Sep 2014 12:20

Publisher DOI:

10.1111/j.1553-2712.1995.tb03145.x

PubMed ID:

8597913

URI:

https://boris.unibe.ch/id/eprint/58555

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