DeBehnke, D J; Swart, G L; Spreng, David; Aufderheide, T P (1995). Standard and higher doses of atropine in a canine model of pulseless electrical activity. Academic emergency medicine, 2(12), pp. 1034-1041. Wiley 10.1111/j.1553-2712.1995.tb03145.x
Full text not available from this repository. (Request a copy)OBJECTIVE
To determine whether standard or increased doses of atropine improve the return of spontaneous circulation (ROSC) rate in a canine model of pulseless electrical activity (PEA).
METHODS
A prospective, controlled, blinded laboratory investigation was performed using an asphyxial canine cardiac arrest model. After the production of asphyxial PEA, 75 dogs remained in untreated PEA for 10 minutes and then were randomized to receive placebo (group 1) or one of four doses of atropine (group 2, 0.04 mg/kg; group 3, 0.1 mg/kg; group 4, 0.2 mg/kg; group 5, 0.4 mg/kg). All the animals received mechanical external CPR and epinephrine (0.02 mg/kg every 3 minutes) throughout resuscitation.
RESULTS
The ROSC rates were not significantly different between the groups (group 1, 73%; group 2, 67%; group 3, 40%; group 4, 47%; group 5, 27%; p = 0.06). The heart rates and hemodynamics during resuscitation were not significantly different between the groups.
CONCLUSION
In this canine model of asphyxial PEA cardiac arrest, standard-dose atropine did not improve ROSC rates, compared with placebo. Increasing doses of atropine tended to decrease ROSC rates, compared with placebo and standard-dose atropine.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic > Small Animal Clinic, Surgery 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic |
UniBE Contributor: |
Spreng, David Emmanuel |
Subjects: |
500 Science 600 Technology > 630 Agriculture |
ISSN: |
1069-6563 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Simone Forterre |
Date Deposited: |
17 Sep 2014 12:20 |
Last Modified: |
02 Mar 2023 23:25 |
Publisher DOI: |
10.1111/j.1553-2712.1995.tb03145.x |
PubMed ID: |
8597913 |
URI: |
https://boris.unibe.ch/id/eprint/58555 |
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