Cognitive and emotional effects of carotid stenosis

Everts, Regula; Wapp, Manuela; Burren, Yuliya; Kellner-Weldon, Frauke; El-Koussy, Marwan; Jann, Kay; Delameilluer Lenoir, Jessica; Michel, Patrik; Schroth, Gerhard (2014). Cognitive and emotional effects of carotid stenosis. Swiss medical weekly, 144, w13970. EMH Schweizerischer Ärzteverlag 10.4414/smw.2014.13970

[img]
Preview
Text
smw-2014-13970.pdf - Published Version
Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND).

Download (435kB) | Preview

PRINCIPLES Patients with carotid artery stenosis (CAS) are at risk of ipsilateral stroke and chronic compromise of cerebral blood flow. It is under debate whether the hypo-perfusion or embolism in CAS is directly related to cognitive impairment. Alternatively, CAS may be a marker for underlying risk factors, which themselves influence cognition. We aimed to determine cognitive performance level and the emotional state of patients with CAS. We hypothesised that patients with high grade stenosis, bilateral stenosis, symptomatic patients and/or those with relevant risk factors would suffer impairment of their cognitive performance and emotional state. METHODS A total of 68 patients with CAS of ≥70% were included in a prospective exploratory study design. All patients underwent structured assessment of executive functions, language, verbal and visual memory, motor speed, anxiety and depression. RESULTS Significantly more patients with CAS showed cognitive impairments (executive functions, word production, verbal and visual memory, motor speed) and anxiety than expected in a normative sample. Bilateral and symptomatic stenosis was associated with slower processing speed. Cognitive performance and anxiety level were not influenced by the side and the degree of stenosis or the presence of collaterals. Factors associated with less cognitive impairment included higher education level, female gender, ambidexterity and treated hypercholesterolemia. CONCLUSIONS Cognitive impairment and increased level of anxiety are frequent in patients with carotid stenosis. The lack of a correlation between cognitive functioning and degree of stenosis or the presence of collaterals, challenges the view that CAS per se leads to cognitive impairment.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > UPD Murtenstrasse
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
10 Strategic Research Centers > Center for Cognition, Learning and Memory (CCLM)

UniBE Contributor:

Everts, Regula; Wapp, Manuela; Burren, Yuliya; Kellner-Weldon, Frauke; El-Koussy, Marwan; Jann, Kay and Schroth, Gerhard

Subjects:

600 Technology > 610 Medicine & health
100 Philosophy > 150 Psychology

ISSN:

1424-7860

Publisher:

EMH Schweizerischer Ärzteverlag

Language:

English

Submitter:

Manuela Wapp

Date Deposited:

06 Oct 2014 13:38

Last Modified:

01 Dec 2017 11:45

Publisher DOI:

10.4414/smw.2014.13970

PubMed ID:

24984222

BORIS DOI:

10.7892/boris.58868

URI:

https://boris.unibe.ch/id/eprint/58868

Actions (login required)

Edit item Edit item
Provide Feedback