Progress in Monitoring alcohol consumption and alcohhol abuse by phosphatidylethanol

Schröck, Alexandra; Thierauf, Annette; Wurst, Friedrich Martin; Thon, Natasha; Weinmann, Wolfgang (2014). Progress in Monitoring alcohol consumption and alcohhol abuse by phosphatidylethanol. Bioanalysis, 6(17), pp. 2285-2294. Future Science 10.4155/BIO.14.195

Text Progress in monitoring alcohol consumption and alcohol abuse by phosphatidylethanol.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (2MB)

For early diagnosis and therapy of alcohol-related disorders,
alcohol biomarkers are highly valuable. Concerning specificity,
indirect markers can be influenced by nonethanol-related factors,
whereas direct markers are only formed after ethanol
consumption. Sensitivity of the direct markers depends on cutoffs
of analytical methods, material for analysis and plays an
important role for their utilization in different fields of application.
Until recently, the biomarker phosphatidylethanol has been used
to differentiate between social drinking and alcohol abuse. After
method optimization, the detection limit could be lowered and
phosphatidylethanol became sensitive enough to even detect the
consumption of low amounts of alcohol. This perspective gives a
summary of most common alcohol biomarkers and summarizes
new developments for monitoring alcohol consumption habits.

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