Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells

Eggimann, Gabriela A.; Blattes, Emilyne; Buschor, Stefanie; Biswas, Rasomoy; Kammer, Stephan M.; Darbre, Tamis; Reymond, Jean-Louis (2014). Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells. Chemical communications, 50(55), pp. 7254-7257. Royal Society of Chemistry 10.1039/C4CC02780A

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Redesigning linear cell penetrating peptides (CPPs) into a multi-branched topology with short dipeptide branches gave cell penetrating peptide dendrimers (CPPDs) with higher cell penetration, lower toxicity and hemolysis and higher serum stability than linear CPPs. Their use is demonstrated by delivering a cytotoxic peptide and paclitaxel into cells.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Blattes, Emilyne; Buschor, Stefanie; Biswas, Rasomoy; Darbre, Tamis and Reymond, Jean-Louis

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry
600 Technology > 610 Medicine & health

ISSN:

1359-7345

Publisher:

Royal Society of Chemistry

Language:

English

Submitter:

Xian Jin

Date Deposited:

10 Nov 2014 09:40

Last Modified:

08 Dec 2014 14:55

Publisher DOI:

10.1039/C4CC02780A

BORIS DOI:

10.7892/boris.60006

URI:

https://boris.unibe.ch/id/eprint/60006

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