Antinociceptive effects of three escalating dexmedetomidine and lignocaine constant rate infusions in conscious horses.

Risberg, A; Spadavecchia, Claudia; Ranheim, B; Krontveit, R; Haga, H A (2014). Antinociceptive effects of three escalating dexmedetomidine and lignocaine constant rate infusions in conscious horses. Veterinary journal, 202(3), pp. 489-497. Elsevier 10.1016/j.tvjl.2014.09.007

[img] Text
1-s2.0-S1090023314003761-main.pdf__tid=a9cd0d9a-8601-11e4-9b28-00000aab0f6b&acdnat=1418830423_487f70591d95a70db7acc4fd9ca8dc35 - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy

Dexmedetomidine and lignocaine IV are used clinically to provide analgesia in horses. The aims of this study were to investigate the antinociceptive effects, plasma concentrations and sedative effects of 2, 4 and 6 µg/kg/h dexmedetomidine IV, with a bolus of 0.96 µg/kg preceding each continuous rate infusion (CRI), and 20, 40 and 60 µg/kg/min lignocaine IV, with a bolus of 550 µg/kg preceding each CRI, in 10 Swiss Warmblood horses. Electrically elicited nociceptive withdrawal reflexes were evaluated by deltoid muscle electromyography. Nociceptive threshold and tolerance were determined by electromyography and behaviour following single and repeated stimulation. Plasma concentrations of drugs were determined by liquid chromatography and mass spectrometry. Sedation was scored on a visual analogue scale. Dexmedetomidine increased nociceptive threshold to single and repeated stimulation for all CRIs, except at 2 µg/kg/h, where no increase in single stimulation nociceptive threshold was observed. Dexmedetomidine increased nociceptive tolerance to single and repeated stimulation at all CRIs. There was large individual variability in dexmedetomidine plasma concentrations and levels of sedation; the median plasma concentration providing antinociceptive effects to all recorded parameters was 0.15 ng/mL, with a range from <0.02 ng/mL (below the lower limit of quantification) to 0.25 ng/mL. Lignocaine increased nociceptive threshold and tolerance to single and repeated stimulation at CRIs of 40 and 60 µg/kg/min, corresponding to plasma lignocaine concentrations >600 ng/mL. Only nociceptive tolerance to repeated stimulation increased at 20 µg/kg/min lignocaine. Lignocaine at 40 µg/kg/min and dexmedetomidine at 4 µg/kg/h were the lowest CRIs resulting in consistent antinociception. Lignocaine did not induce significant sedation.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > NeuroCenter
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Anaesthesiology

UniBE Contributor:

Spadavecchia, Claudia

Subjects:

600 Technology > 630 Agriculture
600 Technology > 610 Medicine & health

ISSN:

1090-0233

Publisher:

Elsevier

Language:

English

Submitter:

Helene Rohrbach Rüegsegger

Date Deposited:

17 Dec 2014 16:32

Last Modified:

15 Oct 2015 09:17

Publisher DOI:

10.1016/j.tvjl.2014.09.007

PubMed ID:

25266648

Uncontrolled Keywords:

Antinociception, Constant rate infusion, Dexmedetomidine, Equine, Lignocaine

BORIS DOI:

10.7892/boris.60858

URI:

https://boris.unibe.ch/id/eprint/60858

Actions (login required)

Edit item Edit item
Provide Feedback