Multiple myeloma-associated amyloidoma of the sacrum: case report and review of the literature.

Klenke, Frank M.; Wirtz, Christian; Banz Wälti, Yara; Keel, Marius; Klass, Natalie Désirée; Novak, Urban; Benneker, Lorin Michael (2014). Multiple myeloma-associated amyloidoma of the sacrum: case report and review of the literature. Global Spine Journal, 4(2), pp. 109-114. Thieme 10.1055/s-0033-1360724

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Study Design Case report. Objectives With only two previously reported cases, localized amyloidosis of the sacrum is extremely rare. Here we report a 64-year-old woman with a large osteolytic lesion accompanied by weakness and paresthesia of the right leg and difficulties in bladder control. Methods Fine needle biopsy and standard staging procedures revealed a primary solitary amyloidoma that was treated with intralesional resection, lumbopelvic stabilization, and consolidation radiotherapy. Results Clinical follow-up revealed the diagnosis of multiple myeloma 9 months after initial treatment. At 12 months, no local recurrence has occurred, the neurologic symptoms have resolved, and the systemic disease is in remission. Conclusions Intralesional resection with adjuvant radiotherapy of the amyloidoma achieved good local tumor control with limited morbidity.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Orthopaedic Surgery
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Klenke, Frank M.; Wirtz, Christian; Banz Wälti, Yara; Keel, Marius; Klass, Natalie Désirée; Novak, Urban and Benneker, Lorin Michael

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

2192-5682

Publisher:

Thieme

Language:

English

Submitter:

Beatrice Scheidegger

Date Deposited:

10 Mar 2015 15:32

Last Modified:

26 Mar 2015 11:05

Publisher DOI:

10.1055/s-0033-1360724

PubMed ID:

25061549

Uncontrolled Keywords:

amyloidosis, multiple myeloma, radiation, sacrum, surgical treatment, tumor

BORIS DOI:

10.7892/boris.61603

URI:

https://boris.unibe.ch/id/eprint/61603

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