Reactivity of hexanuclear ruthenium metallaprisms towards nucleotides and a DNA decamer

Paul, Lydia E. H.; Therrien, Bruno; Furrer, Julien (2015). Reactivity of hexanuclear ruthenium metallaprisms towards nucleotides and a DNA decamer. Journal of biological and inorganic chemistry JBIC, 20(1), pp. 49-59. Springer 10.1007/s00775-014-1208-4

[img] Text
JBIC_2015.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy

The reactivity of three hexacationic arene ruthenium metallaprisms towards isolated nucleotides and a short DNA strand was investigated using NMR spectroscopy, ESI mass spectrometry, UV/Vis and circular dichroism spectroscopy. The metallaprism built from oxalato-bridging ligands reacts rapidly in the presence of deoxyguanosine monophosphate (dGMP) and deoxyadenosine monophosphate, while the benzoquinonato derivative only reacts with dGMP. On the other hand, the larger metallaprism incorporating naphtoquinonato bridges remains stable in the presence of nucleotides. The reactivity of the three hexacationic metallaprisms with the decameric oligonucleotide d(CGCGATCGCG)2 was also investigated. Analysis of the NMR, MS, UV/Vis and CD data suggests that no adducts are formed between the oligonucleotide and the metallaprisms, but electrostatic interactions, leading to partial unwinding of the double-stranded oligonucleotide, were evidenced

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Paul, Lydia and Furrer, Julien

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

0949-8257

Publisher:

Springer

Language:

English

Submitter:

Julien Henri Lucien Furrer

Date Deposited:

26 Jan 2015 15:33

Last Modified:

14 Sep 2015 10:11

Publisher DOI:

10.1007/s00775-014-1208-4

BORIS DOI:

10.7892/boris.61885

URI:

https://boris.unibe.ch/id/eprint/61885

Actions (login required)

Edit item Edit item
Provide Feedback