Paul, Lydia E. H.; Therrien, Bruno; Furrer, Julien (2015). Reactivity of hexanuclear ruthenium metallaprisms towards nucleotides and a DNA decamer. Journal of biological and inorganic chemistry JBIC, 20(1), pp. 49-59. Springer 10.1007/s00775-014-1208-4
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The reactivity of three hexacationic arene ruthenium metallaprisms towards isolated nucleotides and a short DNA strand was investigated using NMR spectroscopy, ESI mass spectrometry, UV/Vis and circular dichroism spectroscopy. The metallaprism built from oxalato-bridging ligands reacts rapidly in the presence of deoxyguanosine monophosphate (dGMP) and deoxyadenosine monophosphate, while the benzoquinonato derivative only reacts with dGMP. On the other hand, the larger metallaprism incorporating naphtoquinonato bridges remains stable in the presence of nucleotides. The reactivity of the three hexacationic metallaprisms with the decameric oligonucleotide d(CGCGATCGCG)2 was also investigated. Analysis of the NMR, MS, UV/Vis and CD data suggests that no adducts are formed between the oligonucleotide and the metallaprisms, but electrostatic interactions, leading to partial unwinding of the double-stranded oligonucleotide, were evidenced
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Paul, Lydia, Furrer, Julien |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
0949-8257 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Julien Henri Lucien Furrer |
Date Deposited: |
26 Jan 2015 15:33 |
Last Modified: |
05 Dec 2022 14:39 |
Publisher DOI: |
10.1007/s00775-014-1208-4 |
BORIS DOI: |
10.7892/boris.61885 |
URI: |
https://boris.unibe.ch/id/eprint/61885 |
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